Role of nitric oxide in hypodipsia of rats with obstructive cholestasis
Cholestasis is associated with the overproduction of nitric oxide (NO), and NO acts as an inhibitory mechanism when thirst is stimulated by water deprivation or by angiotensin II. Due to the presence of hypodipsia in the cholestatic condition, we have compared the rate of water intake between bile d...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2001-02, Vol.53 (2), p.277-281 |
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| creator | Mani, Ali Reza Nahavandi, Arezo Mani, Amir Hossein Dehpour, Ahmad Reza |
| description | Cholestasis is associated with the overproduction of nitric oxide (NO), and NO acts as an inhibitory mechanism when thirst is stimulated by water deprivation or by angiotensin II. Due to the presence of hypodipsia in the cholestatic condition, we have compared the rate of water intake between bile duct‐ligated (cholestatic) and sham‐operated rats. We have evaluated the effect of NO synthesis inhibition by NG‐nitro‐L‐arginine (L‐NNA, 10 mg kg−1/day) on the rate of water intake in cholestatic rats. The results showed that plasma alkaline phosphatase activity (a marker of liver damage) increased after bile‐duct ligation, and that its elevation was partially (but significantly) prevented by treatment with L‐arginine. A two‐week bile‐duct obstruction induced a significant decrease in the rate of water intake compared with sham‐operated animals (35.87 ± 1.45 vs 42.37 ± 1.99 mL/day, P < 0.05). This effect was corrected by the daily administration of L‐NNA. Surprisingly, L‐arginine (200 mg kg−1/day) showed similar activity as L‐NNA in cholestatic rats and increased water intake, but not in control animals. Systemic NO synthesis inhibition corrected the decrease in water intake observed in cholestatic rats. This suggests an important role for NO in the pathophysiology of hypodipsia in cholestatic subjects. The effect of chronic L‐arginine administration observed in cholestatic rats but not seen in the control rats could be explained theoretically by the amelioration of cholestasis‐induced liver damage by chronic L‐arginine administration in bile duct‐ligated rats. |
| doi_str_mv | 10.1211/0022357011775325 |
| format | Article |
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Due to the presence of hypodipsia in the cholestatic condition, we have compared the rate of water intake between bile duct‐ligated (cholestatic) and sham‐operated rats. We have evaluated the effect of NO synthesis inhibition by NG‐nitro‐L‐arginine (L‐NNA, 10 mg kg−1/day) on the rate of water intake in cholestatic rats. The results showed that plasma alkaline phosphatase activity (a marker of liver damage) increased after bile‐duct ligation, and that its elevation was partially (but significantly) prevented by treatment with L‐arginine. A two‐week bile‐duct obstruction induced a significant decrease in the rate of water intake compared with sham‐operated animals (35.87 ± 1.45 vs 42.37 ± 1.99 mL/day, P < 0.05). This effect was corrected by the daily administration of L‐NNA. Surprisingly, L‐arginine (200 mg kg−1/day) showed similar activity as L‐NNA in cholestatic rats and increased water intake, but not in control animals. Systemic NO synthesis inhibition corrected the decrease in water intake observed in cholestatic rats. This suggests an important role for NO in the pathophysiology of hypodipsia in cholestatic subjects. The effect of chronic L‐arginine administration observed in cholestatic rats but not seen in the control rats could be explained theoretically by the amelioration of cholestasis‐induced liver damage by chronic L‐arginine administration in bile duct‐ligated rats.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1211/0022357011775325</identifier><identifier>PMID: 11273028</identifier><identifier>CODEN: JPPMAB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Alkaline Phosphatase - metabolism ; Animals ; Bile Ducts - physiology ; Biological and medical sciences ; Cholestasis - physiopathology ; Cholestasis - psychology ; Digestive system ; Drinking Behavior - drug effects ; Drinking Behavior - physiology ; Enzyme Inhibitors - pharmacology ; Male ; Medical sciences ; Nitric Oxide - physiology ; Nitric Oxide Synthase - antagonists & inhibitors ; omega-N-Methylarginine - therapeutic use ; Pharmacology. 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Due to the presence of hypodipsia in the cholestatic condition, we have compared the rate of water intake between bile duct‐ligated (cholestatic) and sham‐operated rats. We have evaluated the effect of NO synthesis inhibition by NG‐nitro‐L‐arginine (L‐NNA, 10 mg kg−1/day) on the rate of water intake in cholestatic rats. The results showed that plasma alkaline phosphatase activity (a marker of liver damage) increased after bile‐duct ligation, and that its elevation was partially (but significantly) prevented by treatment with L‐arginine. A two‐week bile‐duct obstruction induced a significant decrease in the rate of water intake compared with sham‐operated animals (35.87 ± 1.45 vs 42.37 ± 1.99 mL/day, P < 0.05). This effect was corrected by the daily administration of L‐NNA. Surprisingly, L‐arginine (200 mg kg−1/day) showed similar activity as L‐NNA in cholestatic rats and increased water intake, but not in control animals. Systemic NO synthesis inhibition corrected the decrease in water intake observed in cholestatic rats. This suggests an important role for NO in the pathophysiology of hypodipsia in cholestatic subjects. The effect of chronic L‐arginine administration observed in cholestatic rats but not seen in the control rats could be explained theoretically by the amelioration of cholestasis‐induced liver damage by chronic L‐arginine administration in bile duct‐ligated rats.</description><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Bile Ducts - physiology</subject><subject>Biological and medical sciences</subject><subject>Cholestasis - physiopathology</subject><subject>Cholestasis - psychology</subject><subject>Digestive system</subject><subject>Drinking Behavior - drug effects</subject><subject>Drinking Behavior - physiology</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitric Oxide - physiology</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>omega-N-Methylarginine - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFPwjAUhxujEUTvnswSE2_Ttm9tx9EQHRpQQjQcm9J1oToYtpvAf28JBBMvntrkfd_v5f0QuiT4llBC7jCmFJjAhAjBgLIj1KY4obEgLD1G7e04DnNooTPvPzDGgnN-ilqEUAGYpm2UjavSRFURLWztrI6qtc1NZBfRbLOscrv0Vm2nTtU-Wtl6FlVTX7tG1_bbRHoWZF8rb_05OilU6c3F_u2g98eHt14_HrxmT737QayTpEviVJEpKIWB5l0Q3Twx3SThXCgODAqqYRpuUTkYDrnBnBUpocZAEn5JIZSGDrrZ5S5d9dWE5XJuvTZlqRamarwUmIc8wAHEO1C7yntnCrl0dq7cRhIst-XJv-UF5Wqf3UznJv8V9m0F4HoPKK9VWTi10NYfuJSJVIhAsR21sqXZ_LtWPo_6I5GS4MU7z_rarA-ecp-SCxBMTl4y2Runw2E2GsgJ_ADFOJOt</recordid><startdate>200102</startdate><enddate>200102</enddate><creator>Mani, Ali Reza</creator><creator>Nahavandi, Arezo</creator><creator>Mani, Amir Hossein</creator><creator>Dehpour, Ahmad Reza</creator><general>Blackwell Publishing Ltd</general><general>Pharmaceutical Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200102</creationdate><title>Role of nitric oxide in hypodipsia of rats with obstructive cholestasis</title><author>Mani, Ali Reza ; Nahavandi, Arezo ; Mani, Amir Hossein ; Dehpour, Ahmad Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4491-8a1b3aa032d9379d4e944667a6353f2c3b011ad3e63de065f812ee3465f4f7ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Bile Ducts - physiology</topic><topic>Biological and medical sciences</topic><topic>Cholestasis - physiopathology</topic><topic>Cholestasis - psychology</topic><topic>Digestive system</topic><topic>Drinking Behavior - drug effects</topic><topic>Drinking Behavior - physiology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitric Oxide - physiology</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>omega-N-Methylarginine - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mani, Ali Reza</creatorcontrib><creatorcontrib>Nahavandi, Arezo</creatorcontrib><creatorcontrib>Mani, Amir Hossein</creatorcontrib><creatorcontrib>Dehpour, Ahmad Reza</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mani, Ali Reza</au><au>Nahavandi, Arezo</au><au>Mani, Amir Hossein</au><au>Dehpour, Ahmad Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of nitric oxide in hypodipsia of rats with obstructive cholestasis</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2001-02</date><risdate>2001</risdate><volume>53</volume><issue>2</issue><spage>277</spage><epage>281</epage><pages>277-281</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><coden>JPPMAB</coden><abstract>Cholestasis is associated with the overproduction of nitric oxide (NO), and NO acts as an inhibitory mechanism when thirst is stimulated by water deprivation or by angiotensin II. Due to the presence of hypodipsia in the cholestatic condition, we have compared the rate of water intake between bile duct‐ligated (cholestatic) and sham‐operated rats. We have evaluated the effect of NO synthesis inhibition by NG‐nitro‐L‐arginine (L‐NNA, 10 mg kg−1/day) on the rate of water intake in cholestatic rats. The results showed that plasma alkaline phosphatase activity (a marker of liver damage) increased after bile‐duct ligation, and that its elevation was partially (but significantly) prevented by treatment with L‐arginine. A two‐week bile‐duct obstruction induced a significant decrease in the rate of water intake compared with sham‐operated animals (35.87 ± 1.45 vs 42.37 ± 1.99 mL/day, P < 0.05). This effect was corrected by the daily administration of L‐NNA. Surprisingly, L‐arginine (200 mg kg−1/day) showed similar activity as L‐NNA in cholestatic rats and increased water intake, but not in control animals. Systemic NO synthesis inhibition corrected the decrease in water intake observed in cholestatic rats. This suggests an important role for NO in the pathophysiology of hypodipsia in cholestatic subjects. The effect of chronic L‐arginine administration observed in cholestatic rats but not seen in the control rats could be explained theoretically by the amelioration of cholestasis‐induced liver damage by chronic L‐arginine administration in bile duct‐ligated rats.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>11273028</pmid><doi>10.1211/0022357011775325</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alkaline Phosphatase - metabolism Animals Bile Ducts - physiology Biological and medical sciences Cholestasis - physiopathology Cholestasis - psychology Digestive system Drinking Behavior - drug effects Drinking Behavior - physiology Enzyme Inhibitors - pharmacology Male Medical sciences Nitric Oxide - physiology Nitric Oxide Synthase - antagonists & inhibitors omega-N-Methylarginine - therapeutic use Pharmacology. Drug treatments Rats Rats, Sprague-Dawley |
| title | Role of nitric oxide in hypodipsia of rats with obstructive cholestasis |
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