Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis
Abstract Objective This study was conducted to determine the prevalence of Chlamydia trachomatis (CT) in the endometrium of depot medroxyprogesterone acetate (DMPA) users with and without breakthrough bleeding (BTB) (unscheduled bleeding) and/or chronic endometritis (CE). Methods Cross-sectional stu...
Gespeichert in:
Veröffentlicht in: | Contraception (Stoneham) 2007-07, Vol.76 (1), p.49-52 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 52 |
---|---|
container_issue | 1 |
container_start_page | 49 |
container_title | Contraception (Stoneham) |
container_volume | 76 |
creator | Thurman, Andrea Ries Livengood, Charles H Soper, David E |
description | Abstract Objective This study was conducted to determine the prevalence of Chlamydia trachomatis (CT) in the endometrium of depot medroxyprogesterone acetate (DMPA) users with and without breakthrough bleeding (BTB) (unscheduled bleeding) and/or chronic endometritis (CE). Methods Cross-sectional study. Endometrial biopsies were performed on 20 DMPA users who were having BTB and 20 DMPA users who were amenorrheic. The paraffin-embedded tissue sections were washed with xylene and ethanol to remove the paraffin. CT was identified in the endometrial samples using the COBAS AMPLICOR™ (Roche Diagnostics, Branchburg, NJ, USA) polymerase chain reaction (PCR) identification system. Results Chronic endometritis was the most common histologic finding (10/40, 25%) and occurred more often in women experiencing BTB (35% vs. 15%) (RR 1.62, CI 0.91–2.87). No patient with CE had CT infection of the endometrium or cervix. Conclusions CT was not a cause of CE in this population of at-risk patients using DMPA. It is possible that CE in DMPA users reflects an inflammatory state, a function of an atrophic endometrium. This points to the possibility of nonsteroidal anti-inflammatory drugs as therapy for CE in this population rather than antimicrobials or hormonal medication. |
doi_str_mv | 10.1016/j.contraception.2007.03.006 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70646448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0010782407001436</els_id><sourcerecordid>70646448</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-d7f5d5cb6eba6b1aa74902edc93df0c486934ef5805e30a330c4102860c17c843</originalsourceid><addsrcrecordid>eNqNkdGK1DAUhoMo7rj6ClIQvet40qRJiiAs4-66sKKgXodMcspkbJMxaYV5e1NmYNUrrxLC958Tvp-QVxTWFKh4u1_bGKZkLB4mH8O6AZBrYGsA8YisqJJdDS1Vj8kKgEItVcMvyLOc91DArpVPyQWVrRKUyRW52-xSDN5WGFwccUp-8rnyofrw6ctVNWdMuTLBVZvdYMaj86ZaNu_iaBbuz9Bz8qQ3Q8YX5_OSfL-5_rb5WN9_vr3bXN3Xlnd0qp3sW9farcCtEVtqjOQdNOhsx1wPlivRMY59q6BFBoax8kahUQIslVZxdknenOYeUvw5Y5706LPFYTAB45y1BMEF56qA706gTTHnhL0-JD-adNQU9GJS7_VfJvViUgPTxWRJvzyvmbcjuofsWV0BXp8Bk60Z-mSC9fmBUx2IhreFuz5xWKT88ph0th6DRecT2km76P_zQ-__mWMHX5ozww88Yt7HOYXiXVOdGw3661L-0j3IcuNMsN9klq6k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70646448</pqid></control><display><type>article</type><title>Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Thurman, Andrea Ries ; Livengood, Charles H ; Soper, David E</creator><creatorcontrib>Thurman, Andrea Ries ; Livengood, Charles H ; Soper, David E</creatorcontrib><description>Abstract Objective This study was conducted to determine the prevalence of Chlamydia trachomatis (CT) in the endometrium of depot medroxyprogesterone acetate (DMPA) users with and without breakthrough bleeding (BTB) (unscheduled bleeding) and/or chronic endometritis (CE). Methods Cross-sectional study. Endometrial biopsies were performed on 20 DMPA users who were having BTB and 20 DMPA users who were amenorrheic. The paraffin-embedded tissue sections were washed with xylene and ethanol to remove the paraffin. CT was identified in the endometrial samples using the COBAS AMPLICOR™ (Roche Diagnostics, Branchburg, NJ, USA) polymerase chain reaction (PCR) identification system. Results Chronic endometritis was the most common histologic finding (10/40, 25%) and occurred more often in women experiencing BTB (35% vs. 15%) (RR 1.62, CI 0.91–2.87). No patient with CE had CT infection of the endometrium or cervix. Conclusions CT was not a cause of CE in this population of at-risk patients using DMPA. It is possible that CE in DMPA users reflects an inflammatory state, a function of an atrophic endometrium. This points to the possibility of nonsteroidal anti-inflammatory drugs as therapy for CE in this population rather than antimicrobials or hormonal medication.</description><identifier>ISSN: 0010-7824</identifier><identifier>EISSN: 1879-0518</identifier><identifier>DOI: 10.1016/j.contraception.2007.03.006</identifier><identifier>PMID: 17586137</identifier><identifier>CODEN: CCPTAY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Bacterial diseases ; Bacterial diseases of the genital system ; Biological and medical sciences ; Biopsy ; Birth control ; Chlamydia ; Chlamydia Infections - epidemiology ; Chlamydia Infections - etiology ; Chlamydia Infections - pathology ; Chlamydia trachomatis - genetics ; Chlamydia trachomatis - isolation & purification ; Chronic Disease ; Chronic endometritis ; Contraceptive Agents, Female ; Cross-Sectional Studies ; Delayed-Action Preparations ; Depot medroxyprogesterone acetate ; DNA, Bacterial - analysis ; Drug toxicity and drugs side effects treatment ; Endometritis - epidemiology ; Endometritis - etiology ; Endometritis - pathology ; Female ; Gynecology. Andrology. Obstetrics ; Hormonal contraception ; Human bacterial diseases ; Humans ; Infectious diseases ; Medical sciences ; Medroxyprogesterone Acetate ; Obstetrics and Gynecology ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Prevalence ; South Carolina - epidemiology ; Toxicity: urogenital system</subject><ispartof>Contraception (Stoneham), 2007-07, Vol.76 (1), p.49-52</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-d7f5d5cb6eba6b1aa74902edc93df0c486934ef5805e30a330c4102860c17c843</citedby><cites>FETCH-LOGICAL-c491t-d7f5d5cb6eba6b1aa74902edc93df0c486934ef5805e30a330c4102860c17c843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.contraception.2007.03.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18906245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17586137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thurman, Andrea Ries</creatorcontrib><creatorcontrib>Livengood, Charles H</creatorcontrib><creatorcontrib>Soper, David E</creatorcontrib><title>Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis</title><title>Contraception (Stoneham)</title><addtitle>Contraception</addtitle><description>Abstract Objective This study was conducted to determine the prevalence of Chlamydia trachomatis (CT) in the endometrium of depot medroxyprogesterone acetate (DMPA) users with and without breakthrough bleeding (BTB) (unscheduled bleeding) and/or chronic endometritis (CE). Methods Cross-sectional study. Endometrial biopsies were performed on 20 DMPA users who were having BTB and 20 DMPA users who were amenorrheic. The paraffin-embedded tissue sections were washed with xylene and ethanol to remove the paraffin. CT was identified in the endometrial samples using the COBAS AMPLICOR™ (Roche Diagnostics, Branchburg, NJ, USA) polymerase chain reaction (PCR) identification system. Results Chronic endometritis was the most common histologic finding (10/40, 25%) and occurred more often in women experiencing BTB (35% vs. 15%) (RR 1.62, CI 0.91–2.87). No patient with CE had CT infection of the endometrium or cervix. Conclusions CT was not a cause of CE in this population of at-risk patients using DMPA. It is possible that CE in DMPA users reflects an inflammatory state, a function of an atrophic endometrium. This points to the possibility of nonsteroidal anti-inflammatory drugs as therapy for CE in this population rather than antimicrobials or hormonal medication.</description><subject>Bacterial diseases</subject><subject>Bacterial diseases of the genital system</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Birth control</subject><subject>Chlamydia</subject><subject>Chlamydia Infections - epidemiology</subject><subject>Chlamydia Infections - etiology</subject><subject>Chlamydia Infections - pathology</subject><subject>Chlamydia trachomatis - genetics</subject><subject>Chlamydia trachomatis - isolation & purification</subject><subject>Chronic Disease</subject><subject>Chronic endometritis</subject><subject>Contraceptive Agents, Female</subject><subject>Cross-Sectional Studies</subject><subject>Delayed-Action Preparations</subject><subject>Depot medroxyprogesterone acetate</subject><subject>DNA, Bacterial - analysis</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Endometritis - epidemiology</subject><subject>Endometritis - etiology</subject><subject>Endometritis - pathology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hormonal contraception</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Medroxyprogesterone Acetate</subject><subject>Obstetrics and Gynecology</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Prevalence</subject><subject>South Carolina - epidemiology</subject><subject>Toxicity: urogenital system</subject><issn>0010-7824</issn><issn>1879-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdGK1DAUhoMo7rj6ClIQvet40qRJiiAs4-66sKKgXodMcspkbJMxaYV5e1NmYNUrrxLC958Tvp-QVxTWFKh4u1_bGKZkLB4mH8O6AZBrYGsA8YisqJJdDS1Vj8kKgEItVcMvyLOc91DArpVPyQWVrRKUyRW52-xSDN5WGFwccUp-8rnyofrw6ctVNWdMuTLBVZvdYMaj86ZaNu_iaBbuz9Bz8qQ3Q8YX5_OSfL-5_rb5WN9_vr3bXN3Xlnd0qp3sW9farcCtEVtqjOQdNOhsx1wPlivRMY59q6BFBoax8kahUQIslVZxdknenOYeUvw5Y5706LPFYTAB45y1BMEF56qA706gTTHnhL0-JD-adNQU9GJS7_VfJvViUgPTxWRJvzyvmbcjuofsWV0BXp8Bk60Z-mSC9fmBUx2IhreFuz5xWKT88ph0th6DRecT2km76P_zQ-__mWMHX5ozww88Yt7HOYXiXVOdGw3661L-0j3IcuNMsN9klq6k</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Thurman, Andrea Ries</creator><creator>Livengood, Charles H</creator><creator>Soper, David E</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis</title><author>Thurman, Andrea Ries ; Livengood, Charles H ; Soper, David E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-d7f5d5cb6eba6b1aa74902edc93df0c486934ef5805e30a330c4102860c17c843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Bacterial diseases</topic><topic>Bacterial diseases of the genital system</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Birth control</topic><topic>Chlamydia</topic><topic>Chlamydia Infections - epidemiology</topic><topic>Chlamydia Infections - etiology</topic><topic>Chlamydia Infections - pathology</topic><topic>Chlamydia trachomatis - genetics</topic><topic>Chlamydia trachomatis - isolation & purification</topic><topic>Chronic Disease</topic><topic>Chronic endometritis</topic><topic>Contraceptive Agents, Female</topic><topic>Cross-Sectional Studies</topic><topic>Delayed-Action Preparations</topic><topic>Depot medroxyprogesterone acetate</topic><topic>DNA, Bacterial - analysis</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Endometritis - epidemiology</topic><topic>Endometritis - etiology</topic><topic>Endometritis - pathology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hormonal contraception</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Medroxyprogesterone Acetate</topic><topic>Obstetrics and Gynecology</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Prevalence</topic><topic>South Carolina - epidemiology</topic><topic>Toxicity: urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thurman, Andrea Ries</creatorcontrib><creatorcontrib>Livengood, Charles H</creatorcontrib><creatorcontrib>Soper, David E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contraception (Stoneham)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thurman, Andrea Ries</au><au>Livengood, Charles H</au><au>Soper, David E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis</atitle><jtitle>Contraception (Stoneham)</jtitle><addtitle>Contraception</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>76</volume><issue>1</issue><spage>49</spage><epage>52</epage><pages>49-52</pages><issn>0010-7824</issn><eissn>1879-0518</eissn><coden>CCPTAY</coden><abstract>Abstract Objective This study was conducted to determine the prevalence of Chlamydia trachomatis (CT) in the endometrium of depot medroxyprogesterone acetate (DMPA) users with and without breakthrough bleeding (BTB) (unscheduled bleeding) and/or chronic endometritis (CE). Methods Cross-sectional study. Endometrial biopsies were performed on 20 DMPA users who were having BTB and 20 DMPA users who were amenorrheic. The paraffin-embedded tissue sections were washed with xylene and ethanol to remove the paraffin. CT was identified in the endometrial samples using the COBAS AMPLICOR™ (Roche Diagnostics, Branchburg, NJ, USA) polymerase chain reaction (PCR) identification system. Results Chronic endometritis was the most common histologic finding (10/40, 25%) and occurred more often in women experiencing BTB (35% vs. 15%) (RR 1.62, CI 0.91–2.87). No patient with CE had CT infection of the endometrium or cervix. Conclusions CT was not a cause of CE in this population of at-risk patients using DMPA. It is possible that CE in DMPA users reflects an inflammatory state, a function of an atrophic endometrium. This points to the possibility of nonsteroidal anti-inflammatory drugs as therapy for CE in this population rather than antimicrobials or hormonal medication.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17586137</pmid><doi>10.1016/j.contraception.2007.03.006</doi><tpages>4</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0010-7824 |
ispartof | Contraception (Stoneham), 2007-07, Vol.76 (1), p.49-52 |
issn | 0010-7824 1879-0518 |
language | eng |
recordid | cdi_proquest_miscellaneous_70646448 |
source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
subjects | Bacterial diseases Bacterial diseases of the genital system Biological and medical sciences Biopsy Birth control Chlamydia Chlamydia Infections - epidemiology Chlamydia Infections - etiology Chlamydia Infections - pathology Chlamydia trachomatis - genetics Chlamydia trachomatis - isolation & purification Chronic Disease Chronic endometritis Contraceptive Agents, Female Cross-Sectional Studies Delayed-Action Preparations Depot medroxyprogesterone acetate DNA, Bacterial - analysis Drug toxicity and drugs side effects treatment Endometritis - epidemiology Endometritis - etiology Endometritis - pathology Female Gynecology. Andrology. Obstetrics Hormonal contraception Human bacterial diseases Humans Infectious diseases Medical sciences Medroxyprogesterone Acetate Obstetrics and Gynecology Pharmacology. Drug treatments Polymerase Chain Reaction Prevalence South Carolina - epidemiology Toxicity: urogenital system |
title | Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T17%3A29%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20endometritis%20in%20DMPA%20users%20and%20Chlamydia%20trachomatis%20endometritis&rft.jtitle=Contraception%20(Stoneham)&rft.au=Thurman,%20Andrea%20Ries&rft.date=2007-07-01&rft.volume=76&rft.issue=1&rft.spage=49&rft.epage=52&rft.pages=49-52&rft.issn=0010-7824&rft.eissn=1879-0518&rft.coden=CCPTAY&rft_id=info:doi/10.1016/j.contraception.2007.03.006&rft_dat=%3Cproquest_cross%3E70646448%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70646448&rft_id=info:pmid/17586137&rft_els_id=S0010782407001436&rfr_iscdi=true |