Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis

Abstract Objective This study was conducted to determine the prevalence of Chlamydia trachomatis (CT) in the endometrium of depot medroxyprogesterone acetate (DMPA) users with and without breakthrough bleeding (BTB) (unscheduled bleeding) and/or chronic endometritis (CE). Methods Cross-sectional stu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Contraception (Stoneham) 2007-07, Vol.76 (1), p.49-52
Hauptverfasser: Thurman, Andrea Ries, Livengood, Charles H, Soper, David E
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 52
container_issue 1
container_start_page 49
container_title Contraception (Stoneham)
container_volume 76
creator Thurman, Andrea Ries
Livengood, Charles H
Soper, David E
description Abstract Objective This study was conducted to determine the prevalence of Chlamydia trachomatis (CT) in the endometrium of depot medroxyprogesterone acetate (DMPA) users with and without breakthrough bleeding (BTB) (unscheduled bleeding) and/or chronic endometritis (CE). Methods Cross-sectional study. Endometrial biopsies were performed on 20 DMPA users who were having BTB and 20 DMPA users who were amenorrheic. The paraffin-embedded tissue sections were washed with xylene and ethanol to remove the paraffin. CT was identified in the endometrial samples using the COBAS AMPLICOR™ (Roche Diagnostics, Branchburg, NJ, USA) polymerase chain reaction (PCR) identification system. Results Chronic endometritis was the most common histologic finding (10/40, 25%) and occurred more often in women experiencing BTB (35% vs. 15%) (RR 1.62, CI 0.91–2.87). No patient with CE had CT infection of the endometrium or cervix. Conclusions CT was not a cause of CE in this population of at-risk patients using DMPA. It is possible that CE in DMPA users reflects an inflammatory state, a function of an atrophic endometrium. This points to the possibility of nonsteroidal anti-inflammatory drugs as therapy for CE in this population rather than antimicrobials or hormonal medication.
doi_str_mv 10.1016/j.contraception.2007.03.006
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70646448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0010782407001436</els_id><sourcerecordid>70646448</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-d7f5d5cb6eba6b1aa74902edc93df0c486934ef5805e30a330c4102860c17c843</originalsourceid><addsrcrecordid>eNqNkdGK1DAUhoMo7rj6ClIQvet40qRJiiAs4-66sKKgXodMcspkbJMxaYV5e1NmYNUrrxLC958Tvp-QVxTWFKh4u1_bGKZkLB4mH8O6AZBrYGsA8YisqJJdDS1Vj8kKgEItVcMvyLOc91DArpVPyQWVrRKUyRW52-xSDN5WGFwccUp-8rnyofrw6ctVNWdMuTLBVZvdYMaj86ZaNu_iaBbuz9Bz8qQ3Q8YX5_OSfL-5_rb5WN9_vr3bXN3Xlnd0qp3sW9farcCtEVtqjOQdNOhsx1wPlivRMY59q6BFBoax8kahUQIslVZxdknenOYeUvw5Y5706LPFYTAB45y1BMEF56qA706gTTHnhL0-JD-adNQU9GJS7_VfJvViUgPTxWRJvzyvmbcjuofsWV0BXp8Bk60Z-mSC9fmBUx2IhreFuz5xWKT88ph0th6DRecT2km76P_zQ-__mWMHX5ozww88Yt7HOYXiXVOdGw3661L-0j3IcuNMsN9klq6k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70646448</pqid></control><display><type>article</type><title>Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Thurman, Andrea Ries ; Livengood, Charles H ; Soper, David E</creator><creatorcontrib>Thurman, Andrea Ries ; Livengood, Charles H ; Soper, David E</creatorcontrib><description>Abstract Objective This study was conducted to determine the prevalence of Chlamydia trachomatis (CT) in the endometrium of depot medroxyprogesterone acetate (DMPA) users with and without breakthrough bleeding (BTB) (unscheduled bleeding) and/or chronic endometritis (CE). Methods Cross-sectional study. Endometrial biopsies were performed on 20 DMPA users who were having BTB and 20 DMPA users who were amenorrheic. The paraffin-embedded tissue sections were washed with xylene and ethanol to remove the paraffin. CT was identified in the endometrial samples using the COBAS AMPLICOR™ (Roche Diagnostics, Branchburg, NJ, USA) polymerase chain reaction (PCR) identification system. Results Chronic endometritis was the most common histologic finding (10/40, 25%) and occurred more often in women experiencing BTB (35% vs. 15%) (RR 1.62, CI 0.91–2.87). No patient with CE had CT infection of the endometrium or cervix. Conclusions CT was not a cause of CE in this population of at-risk patients using DMPA. It is possible that CE in DMPA users reflects an inflammatory state, a function of an atrophic endometrium. This points to the possibility of nonsteroidal anti-inflammatory drugs as therapy for CE in this population rather than antimicrobials or hormonal medication.</description><identifier>ISSN: 0010-7824</identifier><identifier>EISSN: 1879-0518</identifier><identifier>DOI: 10.1016/j.contraception.2007.03.006</identifier><identifier>PMID: 17586137</identifier><identifier>CODEN: CCPTAY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Bacterial diseases ; Bacterial diseases of the genital system ; Biological and medical sciences ; Biopsy ; Birth control ; Chlamydia ; Chlamydia Infections - epidemiology ; Chlamydia Infections - etiology ; Chlamydia Infections - pathology ; Chlamydia trachomatis - genetics ; Chlamydia trachomatis - isolation &amp; purification ; Chronic Disease ; Chronic endometritis ; Contraceptive Agents, Female ; Cross-Sectional Studies ; Delayed-Action Preparations ; Depot medroxyprogesterone acetate ; DNA, Bacterial - analysis ; Drug toxicity and drugs side effects treatment ; Endometritis - epidemiology ; Endometritis - etiology ; Endometritis - pathology ; Female ; Gynecology. Andrology. Obstetrics ; Hormonal contraception ; Human bacterial diseases ; Humans ; Infectious diseases ; Medical sciences ; Medroxyprogesterone Acetate ; Obstetrics and Gynecology ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Prevalence ; South Carolina - epidemiology ; Toxicity: urogenital system</subject><ispartof>Contraception (Stoneham), 2007-07, Vol.76 (1), p.49-52</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-d7f5d5cb6eba6b1aa74902edc93df0c486934ef5805e30a330c4102860c17c843</citedby><cites>FETCH-LOGICAL-c491t-d7f5d5cb6eba6b1aa74902edc93df0c486934ef5805e30a330c4102860c17c843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.contraception.2007.03.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=18906245$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17586137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Thurman, Andrea Ries</creatorcontrib><creatorcontrib>Livengood, Charles H</creatorcontrib><creatorcontrib>Soper, David E</creatorcontrib><title>Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis</title><title>Contraception (Stoneham)</title><addtitle>Contraception</addtitle><description>Abstract Objective This study was conducted to determine the prevalence of Chlamydia trachomatis (CT) in the endometrium of depot medroxyprogesterone acetate (DMPA) users with and without breakthrough bleeding (BTB) (unscheduled bleeding) and/or chronic endometritis (CE). Methods Cross-sectional study. Endometrial biopsies were performed on 20 DMPA users who were having BTB and 20 DMPA users who were amenorrheic. The paraffin-embedded tissue sections were washed with xylene and ethanol to remove the paraffin. CT was identified in the endometrial samples using the COBAS AMPLICOR™ (Roche Diagnostics, Branchburg, NJ, USA) polymerase chain reaction (PCR) identification system. Results Chronic endometritis was the most common histologic finding (10/40, 25%) and occurred more often in women experiencing BTB (35% vs. 15%) (RR 1.62, CI 0.91–2.87). No patient with CE had CT infection of the endometrium or cervix. Conclusions CT was not a cause of CE in this population of at-risk patients using DMPA. It is possible that CE in DMPA users reflects an inflammatory state, a function of an atrophic endometrium. This points to the possibility of nonsteroidal anti-inflammatory drugs as therapy for CE in this population rather than antimicrobials or hormonal medication.</description><subject>Bacterial diseases</subject><subject>Bacterial diseases of the genital system</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Birth control</subject><subject>Chlamydia</subject><subject>Chlamydia Infections - epidemiology</subject><subject>Chlamydia Infections - etiology</subject><subject>Chlamydia Infections - pathology</subject><subject>Chlamydia trachomatis - genetics</subject><subject>Chlamydia trachomatis - isolation &amp; purification</subject><subject>Chronic Disease</subject><subject>Chronic endometritis</subject><subject>Contraceptive Agents, Female</subject><subject>Cross-Sectional Studies</subject><subject>Delayed-Action Preparations</subject><subject>Depot medroxyprogesterone acetate</subject><subject>DNA, Bacterial - analysis</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Endometritis - epidemiology</subject><subject>Endometritis - etiology</subject><subject>Endometritis - pathology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hormonal contraception</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Medroxyprogesterone Acetate</subject><subject>Obstetrics and Gynecology</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Prevalence</subject><subject>South Carolina - epidemiology</subject><subject>Toxicity: urogenital system</subject><issn>0010-7824</issn><issn>1879-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdGK1DAUhoMo7rj6ClIQvet40qRJiiAs4-66sKKgXodMcspkbJMxaYV5e1NmYNUrrxLC958Tvp-QVxTWFKh4u1_bGKZkLB4mH8O6AZBrYGsA8YisqJJdDS1Vj8kKgEItVcMvyLOc91DArpVPyQWVrRKUyRW52-xSDN5WGFwccUp-8rnyofrw6ctVNWdMuTLBVZvdYMaj86ZaNu_iaBbuz9Bz8qQ3Q8YX5_OSfL-5_rb5WN9_vr3bXN3Xlnd0qp3sW9farcCtEVtqjOQdNOhsx1wPlivRMY59q6BFBoax8kahUQIslVZxdknenOYeUvw5Y5706LPFYTAB45y1BMEF56qA706gTTHnhL0-JD-adNQU9GJS7_VfJvViUgPTxWRJvzyvmbcjuofsWV0BXp8Bk60Z-mSC9fmBUx2IhreFuz5xWKT88ph0th6DRecT2km76P_zQ-__mWMHX5ozww88Yt7HOYXiXVOdGw3661L-0j3IcuNMsN9klq6k</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Thurman, Andrea Ries</creator><creator>Livengood, Charles H</creator><creator>Soper, David E</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis</title><author>Thurman, Andrea Ries ; Livengood, Charles H ; Soper, David E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-d7f5d5cb6eba6b1aa74902edc93df0c486934ef5805e30a330c4102860c17c843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Bacterial diseases</topic><topic>Bacterial diseases of the genital system</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Birth control</topic><topic>Chlamydia</topic><topic>Chlamydia Infections - epidemiology</topic><topic>Chlamydia Infections - etiology</topic><topic>Chlamydia Infections - pathology</topic><topic>Chlamydia trachomatis - genetics</topic><topic>Chlamydia trachomatis - isolation &amp; purification</topic><topic>Chronic Disease</topic><topic>Chronic endometritis</topic><topic>Contraceptive Agents, Female</topic><topic>Cross-Sectional Studies</topic><topic>Delayed-Action Preparations</topic><topic>Depot medroxyprogesterone acetate</topic><topic>DNA, Bacterial - analysis</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Endometritis - epidemiology</topic><topic>Endometritis - etiology</topic><topic>Endometritis - pathology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hormonal contraception</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Medroxyprogesterone Acetate</topic><topic>Obstetrics and Gynecology</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Prevalence</topic><topic>South Carolina - epidemiology</topic><topic>Toxicity: urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thurman, Andrea Ries</creatorcontrib><creatorcontrib>Livengood, Charles H</creatorcontrib><creatorcontrib>Soper, David E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contraception (Stoneham)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thurman, Andrea Ries</au><au>Livengood, Charles H</au><au>Soper, David E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis</atitle><jtitle>Contraception (Stoneham)</jtitle><addtitle>Contraception</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>76</volume><issue>1</issue><spage>49</spage><epage>52</epage><pages>49-52</pages><issn>0010-7824</issn><eissn>1879-0518</eissn><coden>CCPTAY</coden><abstract>Abstract Objective This study was conducted to determine the prevalence of Chlamydia trachomatis (CT) in the endometrium of depot medroxyprogesterone acetate (DMPA) users with and without breakthrough bleeding (BTB) (unscheduled bleeding) and/or chronic endometritis (CE). Methods Cross-sectional study. Endometrial biopsies were performed on 20 DMPA users who were having BTB and 20 DMPA users who were amenorrheic. The paraffin-embedded tissue sections were washed with xylene and ethanol to remove the paraffin. CT was identified in the endometrial samples using the COBAS AMPLICOR™ (Roche Diagnostics, Branchburg, NJ, USA) polymerase chain reaction (PCR) identification system. Results Chronic endometritis was the most common histologic finding (10/40, 25%) and occurred more often in women experiencing BTB (35% vs. 15%) (RR 1.62, CI 0.91–2.87). No patient with CE had CT infection of the endometrium or cervix. Conclusions CT was not a cause of CE in this population of at-risk patients using DMPA. It is possible that CE in DMPA users reflects an inflammatory state, a function of an atrophic endometrium. This points to the possibility of nonsteroidal anti-inflammatory drugs as therapy for CE in this population rather than antimicrobials or hormonal medication.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17586137</pmid><doi>10.1016/j.contraception.2007.03.006</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0010-7824
ispartof Contraception (Stoneham), 2007-07, Vol.76 (1), p.49-52
issn 0010-7824
1879-0518
language eng
recordid cdi_proquest_miscellaneous_70646448
source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Bacterial diseases
Bacterial diseases of the genital system
Biological and medical sciences
Biopsy
Birth control
Chlamydia
Chlamydia Infections - epidemiology
Chlamydia Infections - etiology
Chlamydia Infections - pathology
Chlamydia trachomatis - genetics
Chlamydia trachomatis - isolation & purification
Chronic Disease
Chronic endometritis
Contraceptive Agents, Female
Cross-Sectional Studies
Delayed-Action Preparations
Depot medroxyprogesterone acetate
DNA, Bacterial - analysis
Drug toxicity and drugs side effects treatment
Endometritis - epidemiology
Endometritis - etiology
Endometritis - pathology
Female
Gynecology. Andrology. Obstetrics
Hormonal contraception
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Medroxyprogesterone Acetate
Obstetrics and Gynecology
Pharmacology. Drug treatments
Polymerase Chain Reaction
Prevalence
South Carolina - epidemiology
Toxicity: urogenital system
title Chronic endometritis in DMPA users and Chlamydia trachomatis endometritis
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T17%3A29%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20endometritis%20in%20DMPA%20users%20and%20Chlamydia%20trachomatis%20endometritis&rft.jtitle=Contraception%20(Stoneham)&rft.au=Thurman,%20Andrea%20Ries&rft.date=2007-07-01&rft.volume=76&rft.issue=1&rft.spage=49&rft.epage=52&rft.pages=49-52&rft.issn=0010-7824&rft.eissn=1879-0518&rft.coden=CCPTAY&rft_id=info:doi/10.1016/j.contraception.2007.03.006&rft_dat=%3Cproquest_cross%3E70646448%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70646448&rft_id=info:pmid/17586137&rft_els_id=S0010782407001436&rfr_iscdi=true