Expression and function of the IL-2 receptor in activated human plasmacytoid dendritic cells

Human and mouse plasmacytoid dendritic cells (PDC) express IL-2 mRNA specifically upon TLR stimulation, but not under CD40L stimulation. Even though the expression of the IL-2R by PDC has been described, the functional implications of this expression remain unknown. Here, we investigated the express...

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Veröffentlicht in:	European Journal of Immunology 2007-07, Vol.37 (7), p.1764-1772
Hauptverfasser:	Naranjo-Gómez, Mar, Oliva, Harold, Climent, Nuria, Fernández, Marco A, Ruiz-Riol, Marta, Bofill, Margarita, Gatell, José M, Gallart, Teresa, Pujol-Borrell, Ricardo, Borràs, Francesc E
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adjuvants, Immunologic CD25 CD40 Ligand - immunology CD40 Ligand - metabolism Cells, Cultured CpG Islands - immunology Cytokine secretion Dendritic Cells - immunology Dendritic Cells - metabolism Flow Cytometry Humans Interleukin-2 Receptor alpha Subunit - immunology Interleukin-2 Receptor alpha Subunit - metabolism Interleukin 2 Plasmacytoid dendritic cells Receptors, Interleukin-2 - immunology Receptors, Interleukin-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - immunology
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