Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelits (EAE), a model for human multiple sclerosis, is an inducible inflammatory and demyelinating disease of the central nervous system (CNS). Susceptibility to this disease is heritable and is demonstrated by the development of an ascending paralysis accompanied b...

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Veröffentlicht in:	International immunology 2001-03, Vol.13 (3), p.257-264
Hauptverfasser:	Encinas, Jeffrey A., Lees, Marjorie B., Sobel, Raymond A., Symonowicz, Cammie, Weiner, Howard L., Seidman, Christine E., Seidman, J. G., Kuchroo, Vijay K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmune Diseases - pathology C57BL Chromosome Mapping CNS central nervous system Crosses, Genetic disease susceptibility EAE experimental autoimmune encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Female genetic crosses Genetic Linkage genetic markers Genetic Predisposition to Disease Genotype human Immunization inbred strains incidence Inflammation linkage LRS likelihood ratio statistic Male Mice multiple sclerosis Myelin Proteins - immunology Paralysis - etiology Phenotype PLP proteolipid protein quantitative trait Sex Factors SJL Weight Loss
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