A Conformational and Structure−Activity Relationship Study of Cytotoxic 3,5-Bis(arylidene)-4-piperidones and Related N-Acryloyl Analogues

A series of 3,5-bis(arylidene)-4-piperidones 1 and related N-acryloyl analogues 2 were prepared as candidate cytotoxic agents with a view to discerning those structural features which contributed to bioactivity. A number of the compounds were markedly cytotoxic toward murine P388 and L1210 leukemic...

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Veröffentlicht in:	Journal of medicinal chemistry 2001-02, Vol.44 (4), p.586-593
Hauptverfasser:	Dimmock, Jonathan R, Padmanilayam, Maniyan P, Puthucode, Ramanan N, Nazarali, Adil J, Motaganahalli, Narasimhan L, Zello, Gordon A, Quail, J. Wilson, Oloo, Eliud O, Kraatz, Heinz-Bernhard, Prisciak, Jared S, Allen, Theresa M, Santos, Cheryl L, Balzarini, Jan, De Clercq, Erik, Manavathu, Elias K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - chemical synthesis Acrylates - chemistry Acrylates - pharmacology Animals Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Aspergillus fumigatus - drug effects Biological and medical sciences Candida albicans - drug effects Crystallography, X-Ray Drug Screening Assays, Antitumor General aspects Humans Medical sciences Mice Models, Molecular Oxidation-Reduction Pharmacology. Drug treatments Piperidines - chemical synthesis Piperidines - chemistry Piperidines - pharmacology RNA - antagonists & inhibitors RNA - biosynthesis Structure-Activity Relationship Tumor Cells, Cultured
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