Renal expression of endothelial and inducible nitric oxide synthase, and formation of peroxynitrite-modified proteins and reactive oxygen species in Wegener's granulomatosis

To investigate the role of nitric oxide (NO) in glomerular inflammation, the expression of endothelial NO synthase (eNOS) and inducible NOS (iNOS) was studied in conjunction with inflammatory cell influx, H2O2 production, and the formation of nitrotyrosines in renal biopsies from patients with Wegen...

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Veröffentlicht in:	The Journal of pathology 2001-02, Vol.193 (2), p.224-232
Hauptverfasser:	Heeringa, Peter, Bijl, Marc, de Jager-Krikken, Alie, Zandvoort, Andre, Dijkstra, Gerard, Moshage, Han, Cohen Tervaert, Jan W., Tiebosch, Anton T. M. G., Kallenberg, Cees G. M., van Goor, Harry
Format:	Artikel
Sprache:	eng
Schlagworte:	3,3'-Diaminobenzidine Adult Aged Biological and medical sciences Blotting, Western Female Granulomatosis with Polyangiitis - metabolism Humans Hydrogen Peroxide - metabolism Kidney - metabolism Kidneys Lewis X Antigen - immunology Lipopolysaccharide Receptors - immunology Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III nitric oxide synthases nitrotyrosine oxygen radicals Platelet Endothelial Cell Adhesion Molecule-1 - immunology Reactive Oxygen Species - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Tyrosine - analogs & derivatives Tyrosine - biosynthesis Urinary system involvement in other diseases. Miscellaneous Wegener's granulomatosis
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