Anticancer drugs induce increased mitochondrial cytochrome c expression that precedes cell death

Recent studies have demonstrated that cytochrome c plays an important role in cell death. In the present study, we report that teniposide and various other chemotherapeutic agents induced a dose-dependent increase in the expression of the mitochondrial respiratory chain proteins cytochrome c, subuni...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2001-02, Vol.61 (3), p.1038-1044
Hauptverfasser:	Sánchez-Alcázar, J A, Khodjakov, A, Schneider, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Breast Neoplasms - enzymology Breast Neoplasms - pathology Caspase 3 Caspase 9 Caspases - metabolism Cell Adhesion - physiology Cytochrome c Group - biosynthesis Cytochrome c Group - metabolism DNA Fragmentation - drug effects Electron Transport - drug effects Electron Transport - physiology Electron Transport Complex IV - biosynthesis Electron Transport Complex IV - metabolism Enzyme Activation Humans Intracellular Membranes - drug effects Intracellular Membranes - physiology Membrane Potentials - drug effects Microscopy, Fluorescence Mitochondria - drug effects Mitochondria - metabolism Mitochondria - physiology Poly(ADP-ribose) Polymerases - metabolism Teniposide - pharmacology Tumor Cells, Cultured Up-Regulation - drug effects
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