Quantitating tissue specificity of human genes to facilitate biomarker discovery

We describe a method to identify candidate cancer biomarkers by analyzing numeric approximations of tissue specificity of human genes. These approximations were calculated by analyzing predicted tissue expression distributions of genes derived from mapping expressed sequence tags (ESTs) to the human...

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Veröffentlicht in:	Bioinformatics 2007-06, Vol.23 (11), p.1348-1355
Hauptverfasser:	Vasmatzis, George, Klee, Eric W., Kube, Dagmar M., Therneau, Terry M., Kosari, Farhad
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - genetics Chromosome Mapping - methods Expressed Sequence Tags Fundamental and applied biological sciences. Psychology General aspects Genetic Predisposition to Disease - genetics Genome, Human - genetics Humans Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Neoplasm Proteins - genetics Neoplasms - diagnosis Neoplasms - genetics Organ Specificity Reproducibility of Results Sensitivity and Specificity Sequence Analysis, DNA - methods
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