Effect of Tick Removal on Transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Nymphs
The effect of feeding duration on pathogen transmission was studied for individual ticks infected with either laboratory or field strains of the Lyme disease spirochete Borrelia burgdorferi and field strains of Ehrlichia phagocytophila an agent of human granulocytic ehrlichiosis. Infected nymphal Ix...
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| Veröffentlicht in: | The Journal of infectious diseases 2001-03, Vol.183 (5), p.773-778 |
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| creator | des Vignes, Franka Piesman, Joseph Heffernan, Richard Schulze, Terry L. Stafford, Kirby C. Fish, Durland |
| description | The effect of feeding duration on pathogen transmission was studied for individual ticks infected with either laboratory or field strains of the Lyme disease spirochete Borrelia burgdorferi and field strains of Ehrlichia phagocytophila an agent of human granulocytic ehrlichiosis. Infected nymphal Ixodes scapularis were allowed to feed individually on mice, and equal numbers were removed at 24-h intervals for ⩽96 h. Mice were assayed for infection by culture, serologic testing, and polymerase chain reaction (PCR) analysis. Fed ticks were assayed by culture or PCR analysis. Transmission of B. burgdorferi did not occur during the first 24 h among 66 attempts, with maximum transmission occurring between 48 and 72 h. A model estimating the probability of infection from individual ticks removed by patients in a Lyme disease–endemic area yielded an overall probability of 4.6%. Infected I. scapularis nymphs transmitted E. phagocytophila within 24 h in 2 of 3 attempts, which indicates that daily tick removal may not be adequate to prevent human infection with this agent |
| doi_str_mv | 10.1086/318818 |
| format | Article |
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Infected nymphal Ixodes scapularis were allowed to feed individually on mice, and equal numbers were removed at 24-h intervals for ⩽96 h. Mice were assayed for infection by culture, serologic testing, and polymerase chain reaction (PCR) analysis. Fed ticks were assayed by culture or PCR analysis. Transmission of B. burgdorferi did not occur during the first 24 h among 66 attempts, with maximum transmission occurring between 48 and 72 h. A model estimating the probability of infection from individual ticks removed by patients in a Lyme disease–endemic area yielded an overall probability of 4.6%. 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Infected nymphal Ixodes scapularis were allowed to feed individually on mice, and equal numbers were removed at 24-h intervals for ⩽96 h. Mice were assayed for infection by culture, serologic testing, and polymerase chain reaction (PCR) analysis. Fed ticks were assayed by culture or PCR analysis. Transmission of B. burgdorferi did not occur during the first 24 h among 66 attempts, with maximum transmission occurring between 48 and 72 h. A model estimating the probability of infection from individual ticks removed by patients in a Lyme disease–endemic area yielded an overall probability of 4.6%. 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| ispartof | The Journal of infectious diseases, 2001-03, Vol.183 (5), p.773-778 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Arachnid Vectors - microbiology Bacterial diseases Biological and medical sciences Borrelia burgdorferi Borrelia burgdorferi Group - pathogenicity Borrelia infections Disease transmission Ehrlichia - pathogenicity Ehrlichia phagocytophila Ehrlichiosis Ehrlichiosis - prevention & control Ehrlichiosis - transmission Human bacterial diseases Infections Infectious diseases Ixodes - microbiology Ixodes scapularis Ixodidae Lyme disease Lyme Disease - prevention & control Lyme Disease - transmission Major Articles Male Medical sciences Mice Nymph - microbiology Nymphs Polymerase Chain Reaction Rickettsial diseases Serologic Tests Specific Pathogen-Free Organisms Spirochaetales Ticks Time Factors Transmission efficiency Tropical bacterial diseases |
| title | Effect of Tick Removal on Transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis Nymphs |
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