Towards Developing A Non‐SnCl2 Formulation for RP444, A New Radiopharmaceutical for Thrombus Imaging

There are many factors influencing the yield and radiochemical purity (RCP) of the radiopharmaceutical RP444. These include heating temperature, heating time, pH, the use of a buffering agent and a bulking agent, as well as the component (XV066, tricine, TPPTS, and Na99mTcO4) concentration. Through...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2001-02, Vol.90 (2), p.114-123
Hauptverfasser:	Liu, Shuang, Edwards, D.Scott, Harris, Anthony R., Ziegler, Marisa C., Poirier, Michael J., Ewels, Barbara A., Diluzio, Willow R., Hui, Poh
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, High Pressure Liquid Contrast media. Radiopharmaceuticals formulation Glycine - analogs & derivatives Glycine - chemistry Mannitol - chemistry Medical sciences Organotechnetium Compounds - chemistry Peptides, Cyclic - chemistry Pharmacology. Drug treatments Radionuclide Imaging radiopharmaceutical Radiopharmaceuticals - chemistry RP444 Surface-Active Agents - chemistry Thrombosis - diagnostic imaging thrombus imaging Tin Compounds - chemistry
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