Phenotype ontologies: the bridge between genomics and evolution
Understanding the developmental and genetic underpinnings of particular evolutionary changes has been hindered by inadequate databases of evolutionary anatomy and by the lack of a computational approach to identify underlying candidate genes and regulators. By contrast, model organism studies have b...
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| Veröffentlicht in: | Trends in ecology & evolution (Amsterdam) 2007-07, Vol.22 (7), p.345-350 |
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| container_issue | 7 |
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| container_title | Trends in ecology & evolution (Amsterdam) |
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| creator | Mabee, Paula M. Ashburner, Michael Cronk, Quentin Gkoutos, Georgios V. Haendel, Melissa Segerdell, Erik Mungall, Chris Westerfield, Monte |
| description | Understanding the developmental and genetic underpinnings of particular evolutionary changes has been hindered by inadequate databases of evolutionary anatomy and by the lack of a computational approach to identify underlying candidate genes and regulators. By contrast, model organism studies have been enhanced by ontologies shared among genomic databases. Here, we suggest that evolutionary and genomics databases can be developed to exchange and use information through shared phenotype and anatomy ontologies. This would facilitate computing on evolutionary questions pertaining to the genetic basis of evolutionary change, the genetic and developmental bases of correlated characters and independent evolution, biomedical parallels to evolutionary change, and the ecological and paleontological correlates of particular types of change in genes, gene networks and developmental pathways. |
| doi_str_mv | 10.1016/j.tree.2007.03.013 |
| format | Article |
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| ispartof | Trends in ecology & evolution (Amsterdam), 2007-07, Vol.22 (7), p.345-350 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anatomy Animal and plant ecology Animal, plant and microbial ecology Animals Biological and medical sciences Biological Evolution Databases, Factual Fundamental and applied biological sciences. Psychology General aspects Genetics of eukaryotes. Biological and molecular evolution Genomics Genotype Humans Phenotype |
| title | Phenotype ontologies: the bridge between genomics and evolution |
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