MMP-2 and MMP-9 expression in adult and childhood acute lymphatic leukemia (ALL)
In the present study the expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in acute lymphatic leukemia (ALL) is studied with immunocytochemical staining in bone marrow aspirate smears from 75 patients. The material included 20 adult and 55 pediatric ALL patients...
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| Veröffentlicht in: | Leukemia research 2001-02, Vol.25 (2), p.125-131 |
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| creator | Kuittinen, Outi Savolainen, Eeva-Riitta Koistinen, Pirjo Möttönen, Merja Turpeenniemi-Hujanen, Taina |
| description | In the present study the expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in acute lymphatic leukemia (ALL) is studied with immunocytochemical staining in bone marrow aspirate smears from 75 patients. The material included 20 adult and 55 pediatric ALL patients. In 65% of the adult ALL cases the immunoreactive protein for either MMP-2 or MMP-9 or for both the enzymes was seen. A statistically significant correlation (
P 0.027) with MMP-2 positivity and appearance of extramedullary infiltrates was found in adult ALL, suggesting that the gelatinase activity could be related with increased extravasation of the leukemic cells in ALL. This has to be confirmed in a larger patient population. In pediatric patients there were only seven cases (12.7%) out of 55 with positive immunostaining for either of these metalloproteinases. MMP expression correlated with L2 FAB class, high-risk tumor group and T-cell immunophenotype, but not with extramedullary presentation in pediatric patients with ALL indicating basic biological differences between adult and childhood ALL. |
| doi_str_mv | 10.1016/S0145-2126(00)00104-1 |
| format | Article |
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P 0.027) with MMP-2 positivity and appearance of extramedullary infiltrates was found in adult ALL, suggesting that the gelatinase activity could be related with increased extravasation of the leukemic cells in ALL. This has to be confirmed in a larger patient population. In pediatric patients there were only seven cases (12.7%) out of 55 with positive immunostaining for either of these metalloproteinases. MMP expression correlated with L2 FAB class, high-risk tumor group and T-cell immunophenotype, but not with extramedullary presentation in pediatric patients with ALL indicating basic biological differences between adult and childhood ALL.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/S0145-2126(00)00104-1</identifier><identifier>PMID: 11166827</identifier><identifier>CODEN: LEREDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acute lymphocytic leukemia ; Adolescent ; Adult ; Aged ; Biological and medical sciences ; Female ; Hematologic and hematopoietic diseases ; Humans ; Invasion ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinase 9 - metabolism ; Medical sciences ; Middle Aged ; MMP-2 ; MMP-9 ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology ; Prognosis ; Prognostic factors</subject><ispartof>Leukemia research, 2001-02, Vol.25 (2), p.125-131</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-763258437ff1bb469cf01646d9345bec441da796143409cdbfb5e518d4ebc203</citedby><cites>FETCH-LOGICAL-c455t-763258437ff1bb469cf01646d9345bec441da796143409cdbfb5e518d4ebc203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0145212600001041$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=922366$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11166827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuittinen, Outi</creatorcontrib><creatorcontrib>Savolainen, Eeva-Riitta</creatorcontrib><creatorcontrib>Koistinen, Pirjo</creatorcontrib><creatorcontrib>Möttönen, Merja</creatorcontrib><creatorcontrib>Turpeenniemi-Hujanen, Taina</creatorcontrib><title>MMP-2 and MMP-9 expression in adult and childhood acute lymphatic leukemia (ALL)</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>In the present study the expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in acute lymphatic leukemia (ALL) is studied with immunocytochemical staining in bone marrow aspirate smears from 75 patients. The material included 20 adult and 55 pediatric ALL patients. In 65% of the adult ALL cases the immunoreactive protein for either MMP-2 or MMP-9 or for both the enzymes was seen. A statistically significant correlation (
P 0.027) with MMP-2 positivity and appearance of extramedullary infiltrates was found in adult ALL, suggesting that the gelatinase activity could be related with increased extravasation of the leukemic cells in ALL. This has to be confirmed in a larger patient population. In pediatric patients there were only seven cases (12.7%) out of 55 with positive immunostaining for either of these metalloproteinases. MMP expression correlated with L2 FAB class, high-risk tumor group and T-cell immunophenotype, but not with extramedullary presentation in pediatric patients with ALL indicating basic biological differences between adult and childhood ALL.</description><subject>Acute lymphocytic leukemia</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Invasion</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MMP-2</subject><subject>MMP-9</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology</subject><subject>Prognosis</subject><subject>Prognostic factors</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLHTEQgINU9FT7EyyBQtGH1Zlskt19EpFehCMK9T1kk1lO7F6OyW6p_757Luhjn2Zgvrl9jJ0hXCKgvvoFKFUmUOhzgAsABJnhAVtgWeSZKnP1gS3ekGP2MaVnAFAVVkfsGBG1LkWxYI_394-Z4Lb3fJNVnP6uI6UUhp6Hnls_teO26lah9ath8Ny6aSTevnbrlR2D4y1Nv6kLlp_fLJcXp-ywsW2iT_t4wp6-f3u6_ZktH37c3d4sMyeVGrNC50KVMi-aButa6so181dS-yqXqiYnJXpbVBplLqFyvm5qRQpLL6l2AvIT9nU3dh2Hl4nSaLqQHLWt7WmYkilAS6GEmkG1A10cUorUmHUMnY2vBsFsTJqtSbPRZADM1qTBue_zfsFUd-Tfu_bqZuDLHrDJ2baJtnchvXGVELnWM3W9o2h28SdQNMkF6h35EMmNxg_hP4f8A2xxjGc</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Kuittinen, Outi</creator><creator>Savolainen, Eeva-Riitta</creator><creator>Koistinen, Pirjo</creator><creator>Möttönen, Merja</creator><creator>Turpeenniemi-Hujanen, Taina</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>MMP-2 and MMP-9 expression in adult and childhood acute lymphatic leukemia (ALL)</title><author>Kuittinen, Outi ; Savolainen, Eeva-Riitta ; Koistinen, Pirjo ; Möttönen, Merja ; Turpeenniemi-Hujanen, Taina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-763258437ff1bb469cf01646d9345bec441da796143409cdbfb5e518d4ebc203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acute lymphocytic leukemia</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Invasion</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MMP-2</topic><topic>MMP-9</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology</topic><topic>Prognosis</topic><topic>Prognostic factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuittinen, Outi</creatorcontrib><creatorcontrib>Savolainen, Eeva-Riitta</creatorcontrib><creatorcontrib>Koistinen, Pirjo</creatorcontrib><creatorcontrib>Möttönen, Merja</creatorcontrib><creatorcontrib>Turpeenniemi-Hujanen, Taina</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuittinen, Outi</au><au>Savolainen, Eeva-Riitta</au><au>Koistinen, Pirjo</au><au>Möttönen, Merja</au><au>Turpeenniemi-Hujanen, Taina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MMP-2 and MMP-9 expression in adult and childhood acute lymphatic leukemia (ALL)</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>25</volume><issue>2</issue><spage>125</spage><epage>131</epage><pages>125-131</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>In the present study the expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in acute lymphatic leukemia (ALL) is studied with immunocytochemical staining in bone marrow aspirate smears from 75 patients. The material included 20 adult and 55 pediatric ALL patients. In 65% of the adult ALL cases the immunoreactive protein for either MMP-2 or MMP-9 or for both the enzymes was seen. A statistically significant correlation (
P 0.027) with MMP-2 positivity and appearance of extramedullary infiltrates was found in adult ALL, suggesting that the gelatinase activity could be related with increased extravasation of the leukemic cells in ALL. This has to be confirmed in a larger patient population. In pediatric patients there were only seven cases (12.7%) out of 55 with positive immunostaining for either of these metalloproteinases. MMP expression correlated with L2 FAB class, high-risk tumor group and T-cell immunophenotype, but not with extramedullary presentation in pediatric patients with ALL indicating basic biological differences between adult and childhood ALL.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11166827</pmid><doi>10.1016/S0145-2126(00)00104-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Acute lymphocytic leukemia Adolescent Adult Aged Biological and medical sciences Female Hematologic and hematopoietic diseases Humans Invasion Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Medical sciences Middle Aged MMP-2 MMP-9 Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology Prognosis Prognostic factors |
| title | MMP-2 and MMP-9 expression in adult and childhood acute lymphatic leukemia (ALL) |
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