IL-4 Plays a Crucial Role in Regulating Oxidative Damage in the Liver During Schistosomiasis

Liver enlargement and hepatocyte proliferation, normal responses in wild-type (WT) mice infected with the parasitic helminth Schistosoma mansoni, were found to be severely impaired in infected IL-4(-/-) mice. Compared with WT mice, increased levels of O(2)(-), NO, and the more highly reactive ONOO(-...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-02, Vol.166 (3), p.1903-1911
Hauptverfasser:	La Flamme, Anne Camille, Patton, Elisabeth A, Bauman, Beverley, Pearce, Edward J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Antioxidants - administration & dosage Catalase - antagonists & inhibitors Catalase - biosynthesis Cell Division - genetics Cell Division - immunology Female Granuloma - enzymology Granuloma - genetics Granuloma - metabolism Hepatocytes - pathology Injections, Intraperitoneal Interleukin-4 - deficiency Interleukin-4 - genetics Interleukin-4 - physiology Liver - enzymology Liver - immunology Liver - metabolism Liver - pathology Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide - biosynthesis Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Nitrogen - metabolism Oxidative Stress - genetics Oxidative Stress - immunology Reactive Oxygen Species - metabolism Schistosoma mansoni Schistosomiasis mansoni - immunology Schistosomiasis mansoni - metabolism Schistosomiasis mansoni - mortality Schistosomiasis mansoni - pathology Survival Rate Uric Acid - administration & dosage
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