Collagenous fibroma (desmoplastic fibroblastoma) of the palate : A case report
Collagenous fibroma is an uncommon benign soft tissue lesion that has a wide anatomic distribution. We describe a case of a collagenous fibroma that appeared in the left soft and hard palate of a 37-year-old woman as a 5.0-cm solitary, firm nodule. Microscopically, it was composed of stellate or spi...
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| Veröffentlicht in: | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2001, Vol.91 (1), p.80-84 |
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| container_title | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics |
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| creator | ALVES MESQUITA, Ricardo OKUDA, Edson JORGE, Waldir Antonio CAVALCANTI DE ARAUJO, Vera |
| description | Collagenous fibroma is an uncommon benign soft tissue lesion that has a wide anatomic distribution. We describe a case of a collagenous fibroma that appeared in the left soft and hard palate of a 37-year-old woman as a 5.0-cm solitary, firm nodule. Microscopically, it was composed of stellate or spindle-shaped cells embedded in hypovascular fibrous stroma. Entrapment of fat was focally identified at the edges. Mitotic figures and tumor necrosis were absent. Tumor cells were immunopositive for vimentin, and a few cells were positive for alpha-smooth muscle actin. Tumor extracellular matrix was immunopositive for type I and type III collagen, as well as for fibronectin. These findings satisfied the diagnostic criteria for collagenous fibroma (desmoplastic fibroblastoma). This case, to our knowledge, represents the first report of this tumor in the mouth. The differential diagnosis of fibrous lesions of the mouth is discussed. |
| doi_str_mv | 10.1067/moe.2001.109638 |
| format | Article |
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We describe a case of a collagenous fibroma that appeared in the left soft and hard palate of a 37-year-old woman as a 5.0-cm solitary, firm nodule. Microscopically, it was composed of stellate or spindle-shaped cells embedded in hypovascular fibrous stroma. Entrapment of fat was focally identified at the edges. Mitotic figures and tumor necrosis were absent. Tumor cells were immunopositive for vimentin, and a few cells were positive for alpha-smooth muscle actin. Tumor extracellular matrix was immunopositive for type I and type III collagen, as well as for fibronectin. These findings satisfied the diagnostic criteria for collagenous fibroma (desmoplastic fibroblastoma). This case, to our knowledge, represents the first report of this tumor in the mouth. The differential diagnosis of fibrous lesions of the mouth is discussed.</description><identifier>ISSN: 1079-2104</identifier><identifier>EISSN: 1528-395X</identifier><identifier>DOI: 10.1067/moe.2001.109638</identifier><identifier>PMID: 11174576</identifier><language>eng</language><publisher>St. Louis, MO: Elsevier</publisher><subject>Adult ; Biological and medical sciences ; Collagen - analysis ; Dentistry ; Female ; Fibroma, Desmoplastic - pathology ; Humans ; Immunohistochemistry ; Medical sciences ; Otorhinolaryngology. 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We describe a case of a collagenous fibroma that appeared in the left soft and hard palate of a 37-year-old woman as a 5.0-cm solitary, firm nodule. Microscopically, it was composed of stellate or spindle-shaped cells embedded in hypovascular fibrous stroma. Entrapment of fat was focally identified at the edges. Mitotic figures and tumor necrosis were absent. Tumor cells were immunopositive for vimentin, and a few cells were positive for alpha-smooth muscle actin. Tumor extracellular matrix was immunopositive for type I and type III collagen, as well as for fibronectin. These findings satisfied the diagnostic criteria for collagenous fibroma (desmoplastic fibroblastoma). This case, to our knowledge, represents the first report of this tumor in the mouth. The differential diagnosis of fibrous lesions of the mouth is discussed.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Collagen - analysis</subject><subject>Dentistry</subject><subject>Female</subject><subject>Fibroma, Desmoplastic - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Palatal Neoplasms - pathology</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1079-2104</issn><issn>1528-395X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLw0AUhQdRbK2u3cmAILpInUfm5a4EX1B0o-AuzExuNJJ0YiZd-O-d2urqnnPux4VzETqlZE6JVNddgDkjhCZnJNd7aEoF0xk34m0_aaJMxijJJ-goxk9CiOTGHKIJpVTlQskpeipC29p3WIV1xHXjhtBZfFlB7ELf2jg2fpu6jUm7KxxqPH4A7m1rR8A3eIG9jYAH6MMwHqOD2rYRTnZzhl7vbl-Kh2z5fP9YLJZZz7gYM-olVII5TzdKyko47p1RlDNHjLZ1asE0r5x0moAF4V0uSW2V0EClMnyGLrZ3-yF8rSGOZddED6nKClKTUhGZM_YLnu3AteugKvuh6ezwXf59IAHnO8BGb9t6sCvfxH9OS61zzX8AZ5Zp6Q</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>ALVES MESQUITA, Ricardo</creator><creator>OKUDA, Edson</creator><creator>JORGE, Waldir Antonio</creator><creator>CAVALCANTI DE ARAUJO, Vera</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Collagenous fibroma (desmoplastic fibroblastoma) of the palate : A case report</title><author>ALVES MESQUITA, Ricardo ; OKUDA, Edson ; JORGE, Waldir Antonio ; CAVALCANTI DE ARAUJO, Vera</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-1c6ed52bc11c6e66d5b3cb97132b098af152283db6b80eae5cb460fa758e16793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Collagen - analysis</topic><topic>Dentistry</topic><topic>Female</topic><topic>Fibroma, Desmoplastic - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Palatal Neoplasms - pathology</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALVES MESQUITA, Ricardo</creatorcontrib><creatorcontrib>OKUDA, Edson</creatorcontrib><creatorcontrib>JORGE, Waldir Antonio</creatorcontrib><creatorcontrib>CAVALCANTI DE ARAUJO, Vera</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ALVES MESQUITA, Ricardo</au><au>OKUDA, Edson</au><au>JORGE, Waldir Antonio</au><au>CAVALCANTI DE ARAUJO, Vera</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collagenous fibroma (desmoplastic fibroblastoma) of the palate : A case report</atitle><jtitle>Oral surgery, oral medicine, oral pathology, oral radiology and endodontics</jtitle><addtitle>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</addtitle><date>2001</date><risdate>2001</risdate><volume>91</volume><issue>1</issue><spage>80</spage><epage>84</epage><pages>80-84</pages><issn>1079-2104</issn><eissn>1528-395X</eissn><abstract>Collagenous fibroma is an uncommon benign soft tissue lesion that has a wide anatomic distribution. 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| identifier | ISSN: 1079-2104 |
| ispartof | Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 2001, Vol.91 (1), p.80-84 |
| issn | 1079-2104 1528-395X |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Biological and medical sciences Collagen - analysis Dentistry Female Fibroma, Desmoplastic - pathology Humans Immunohistochemistry Medical sciences Otorhinolaryngology. Stomatology Palatal Neoplasms - pathology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Collagenous fibroma (desmoplastic fibroblastoma) of the palate : A case report |
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