Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice
Thymus- and activation-regulated chemokine (TARC; CCL17) is a lymphocyte-directed CC chemokine that specifically chemoattracts CC chemokine receptor 4-positive (CCR4(+)) Th2 cells. To establish the pathophysiological roles of TARC in vivo, we investigated here whether an mAb against TARC could inhib...
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| Veröffentlicht in: | The Journal of immunology (1950) 2001-02, Vol.166 (3), p.2055-2062 |
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| container_title | The Journal of immunology (1950) |
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| creator | Kawasaki, Shin Takizawa, Hajime Yoneyama, Hiroyuki Nakayama, Takashi Fujisawa, Ryuichi Izumizaki, Masahiko Imai, Toshio Yoshie, Osamu Homma, Ikuo Yamamoto, Kazuhiko Matsushima, Kouji |
| description | Thymus- and activation-regulated chemokine (TARC; CCL17) is a lymphocyte-directed CC chemokine that specifically chemoattracts CC chemokine receptor 4-positive (CCR4(+)) Th2 cells. To establish the pathophysiological roles of TARC in vivo, we investigated here whether an mAb against TARC could inhibit the induction of asthmatic reaction in mice elicited by OVA. TARC was constitutively expressed in the lung and was up-regulated in allergic inflammation. The specific Ab against TARC attenuated OVA-induced airway eosinophilia and diminished the degree of airway hyperresponsiveness with a concomitant decrease in Th2 cytokine levels. Our results for the first time indicate that TARC is a pivotal chemokine for the development of Th2-dominated experimental allergen-induced asthma with eosinophilia and AHR. This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine. |
| doi_str_mv | 10.4049/jimmunol.166.3.2055 |
| format | Article |
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To establish the pathophysiological roles of TARC in vivo, we investigated here whether an mAb against TARC could inhibit the induction of asthmatic reaction in mice elicited by OVA. TARC was constitutively expressed in the lung and was up-regulated in allergic inflammation. The specific Ab against TARC attenuated OVA-induced airway eosinophilia and diminished the degree of airway hyperresponsiveness with a concomitant decrease in Th2 cytokine levels. Our results for the first time indicate that TARC is a pivotal chemokine for the development of Th2-dominated experimental allergen-induced asthma with eosinophilia and AHR. This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.166.3.2055</identifier><identifier>PMID: 11160256</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject><![CDATA[Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antibody Specificity ; Asthma - immunology ; Asthma - pathology ; Asthma - prevention & control ; Bronchial Hyperreactivity - immunology ; Bronchial Hyperreactivity - pathology ; Bronchial Hyperreactivity - prevention & control ; CCR4 protein ; CD4-Positive T-Lymphocytes - immunology ; CD4-Positive T-Lymphocytes - pathology ; Cell Movement - immunology ; Chemokine CCL17 ; Chemokines, CC - biosynthesis ; Chemokines, CC - genetics ; Chemokines, CC - immunology ; Chemokines, CC - physiology ; Cytokines - biosynthesis ; Cytokines - metabolism ; Disease Models, Animal ; Immune Sera - administration & dosage ; Immune Sera - pharmacology ; Immunohistochemistry ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - pharmacology ; Injections, Intraperitoneal ; Lung - immunology ; Lung - metabolism ; Lung - pathology ; Lymphocyte Activation ; Male ; Mice ; Mice, Inbred C57BL ; Ovalbumin - administration & dosage ; Ovalbumin - immunology ; Pulmonary Eosinophilia - immunology ; Pulmonary Eosinophilia - prevention & control ; RNA, Messenger - biosynthesis ; TARC protein ; Th2 Cells - immunology ; Th2 Cells - metabolism ; Thymus Gland - immunology]]></subject><ispartof>The Journal of immunology (1950), 2001-02, Vol.166 (3), p.2055-2062</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-de3f7e73ab33c09af8160658ab25b01c01754753b5012a2989fafcd3e7bbf0403</citedby><cites>FETCH-LOGICAL-c475t-de3f7e73ab33c09af8160658ab25b01c01754753b5012a2989fafcd3e7bbf0403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11160256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawasaki, Shin</creatorcontrib><creatorcontrib>Takizawa, Hajime</creatorcontrib><creatorcontrib>Yoneyama, Hiroyuki</creatorcontrib><creatorcontrib>Nakayama, Takashi</creatorcontrib><creatorcontrib>Fujisawa, Ryuichi</creatorcontrib><creatorcontrib>Izumizaki, Masahiko</creatorcontrib><creatorcontrib>Imai, Toshio</creatorcontrib><creatorcontrib>Yoshie, Osamu</creatorcontrib><creatorcontrib>Homma, Ikuo</creatorcontrib><creatorcontrib>Yamamoto, Kazuhiko</creatorcontrib><creatorcontrib>Matsushima, Kouji</creatorcontrib><title>Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Thymus- and activation-regulated chemokine (TARC; CCL17) is a lymphocyte-directed CC chemokine that specifically chemoattracts CC chemokine receptor 4-positive (CCR4(+)) Th2 cells. 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This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Antibody Specificity</subject><subject>Asthma - immunology</subject><subject>Asthma - pathology</subject><subject>Asthma - prevention & control</subject><subject>Bronchial Hyperreactivity - immunology</subject><subject>Bronchial Hyperreactivity - pathology</subject><subject>Bronchial Hyperreactivity - prevention & control</subject><subject>CCR4 protein</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD4-Positive T-Lymphocytes - pathology</subject><subject>Cell Movement - immunology</subject><subject>Chemokine CCL17</subject><subject>Chemokines, CC - biosynthesis</subject><subject>Chemokines, CC - genetics</subject><subject>Chemokines, CC - immunology</subject><subject>Chemokines, CC - physiology</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>Immune Sera - administration & dosage</subject><subject>Immune Sera - pharmacology</subject><subject>Immunohistochemistry</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Injections, Intraperitoneal</subject><subject>Lung - immunology</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Ovalbumin - administration & dosage</subject><subject>Ovalbumin - immunology</subject><subject>Pulmonary Eosinophilia - immunology</subject><subject>Pulmonary Eosinophilia - prevention & control</subject><subject>RNA, Messenger - biosynthesis</subject><subject>TARC protein</subject><subject>Th2 Cells - immunology</subject><subject>Th2 Cells - metabolism</subject><subject>Thymus Gland - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGO0zAQhi0EYrsLT4CEfIJTyjiOnfZYFdittAgJLWfLSSaNF9sJdtKo78ED426L4MbJI883n-z5CXnDYFlAsf7waJybfG-XTMolX-YgxDOyYEJAJiXI52QBkOcZK2V5Ra5jfAQACXnxklwxxlIl5IL82vkRwwH9aHpP-5Y-dEc3Rap9Qzf1aA761Mi-4X6yesSGbjt0_Q_jkW7GEf2ULiMdO6Qf8YC2H1xSnTwbazHsTU03Jsz6SHe-tdq5J92T_e44YAgYh95Hkx6AMVLj6RdT4yvyotU24uvLeUO-f_70sL3L7r_e7rab-6wuSjFmDfK2xJLrivMa1rpdpV9JsdJVLipgNbBSJJBXAliu8_Vq3eq2bjiWVdVCAfyGvDt7h9D_nDCOyplYo7XaYz9FVYIs8rSm_4KsXKWN5jyB_AzWoY8xYKuGYJwOR8VAnVJTf1JTKTXF1Sm1NPX2op8qh83fmUtMCXh_Bjqz72YTUEWnrU04U_M8_6P6DZ5zpk8</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Kawasaki, Shin</creator><creator>Takizawa, Hajime</creator><creator>Yoneyama, Hiroyuki</creator><creator>Nakayama, Takashi</creator><creator>Fujisawa, Ryuichi</creator><creator>Izumizaki, Masahiko</creator><creator>Imai, Toshio</creator><creator>Yoshie, Osamu</creator><creator>Homma, Ikuo</creator><creator>Yamamoto, Kazuhiko</creator><creator>Matsushima, Kouji</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice</title><author>Kawasaki, Shin ; Takizawa, Hajime ; Yoneyama, Hiroyuki ; Nakayama, Takashi ; Fujisawa, Ryuichi ; Izumizaki, Masahiko ; Imai, Toshio ; Yoshie, Osamu ; Homma, Ikuo ; Yamamoto, Kazuhiko ; Matsushima, Kouji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-de3f7e73ab33c09af8160658ab25b01c01754753b5012a2989fafcd3e7bbf0403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Antibody Specificity</topic><topic>Asthma - immunology</topic><topic>Asthma - pathology</topic><topic>Asthma - prevention & control</topic><topic>Bronchial Hyperreactivity - immunology</topic><topic>Bronchial Hyperreactivity - pathology</topic><topic>Bronchial Hyperreactivity - prevention & control</topic><topic>CCR4 protein</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD4-Positive T-Lymphocytes - pathology</topic><topic>Cell Movement - immunology</topic><topic>Chemokine CCL17</topic><topic>Chemokines, CC - biosynthesis</topic><topic>Chemokines, CC - genetics</topic><topic>Chemokines, CC - immunology</topic><topic>Chemokines, CC - physiology</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>Immune Sera - administration & dosage</topic><topic>Immune Sera - pharmacology</topic><topic>Immunohistochemistry</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Injections, Intraperitoneal</topic><topic>Lung - immunology</topic><topic>Lung - metabolism</topic><topic>Lung - pathology</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Ovalbumin - administration & dosage</topic><topic>Ovalbumin - immunology</topic><topic>Pulmonary Eosinophilia - immunology</topic><topic>Pulmonary Eosinophilia - prevention & control</topic><topic>RNA, Messenger - biosynthesis</topic><topic>TARC protein</topic><topic>Th2 Cells - immunology</topic><topic>Th2 Cells - metabolism</topic><topic>Thymus Gland - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawasaki, Shin</creatorcontrib><creatorcontrib>Takizawa, Hajime</creatorcontrib><creatorcontrib>Yoneyama, Hiroyuki</creatorcontrib><creatorcontrib>Nakayama, Takashi</creatorcontrib><creatorcontrib>Fujisawa, Ryuichi</creatorcontrib><creatorcontrib>Izumizaki, Masahiko</creatorcontrib><creatorcontrib>Imai, Toshio</creatorcontrib><creatorcontrib>Yoshie, Osamu</creatorcontrib><creatorcontrib>Homma, Ikuo</creatorcontrib><creatorcontrib>Yamamoto, Kazuhiko</creatorcontrib><creatorcontrib>Matsushima, Kouji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawasaki, Shin</au><au>Takizawa, Hajime</au><au>Yoneyama, Hiroyuki</au><au>Nakayama, Takashi</au><au>Fujisawa, Ryuichi</au><au>Izumizaki, Masahiko</au><au>Imai, Toshio</au><au>Yoshie, Osamu</au><au>Homma, Ikuo</au><au>Yamamoto, Kazuhiko</au><au>Matsushima, Kouji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>166</volume><issue>3</issue><spage>2055</spage><epage>2062</epage><pages>2055-2062</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Thymus- and activation-regulated chemokine (TARC; CCL17) is a lymphocyte-directed CC chemokine that specifically chemoattracts CC chemokine receptor 4-positive (CCR4(+)) Th2 cells. To establish the pathophysiological roles of TARC in vivo, we investigated here whether an mAb against TARC could inhibit the induction of asthmatic reaction in mice elicited by OVA. TARC was constitutively expressed in the lung and was up-regulated in allergic inflammation. The specific Ab against TARC attenuated OVA-induced airway eosinophilia and diminished the degree of airway hyperresponsiveness with a concomitant decrease in Th2 cytokine levels. Our results for the first time indicate that TARC is a pivotal chemokine for the development of Th2-dominated experimental allergen-induced asthma with eosinophilia and AHR. This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>11160256</pmid><doi>10.4049/jimmunol.166.3.2055</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of immunology (1950), 2001-02, Vol.166 (3), p.2055-2062 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibody Specificity Asthma - immunology Asthma - pathology Asthma - prevention & control Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - pathology Bronchial Hyperreactivity - prevention & control CCR4 protein CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology Cell Movement - immunology Chemokine CCL17 Chemokines, CC - biosynthesis Chemokines, CC - genetics Chemokines, CC - immunology Chemokines, CC - physiology Cytokines - biosynthesis Cytokines - metabolism Disease Models, Animal Immune Sera - administration & dosage Immune Sera - pharmacology Immunohistochemistry Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacology Injections, Intraperitoneal Lung - immunology Lung - metabolism Lung - pathology Lymphocyte Activation Male Mice Mice, Inbred C57BL Ovalbumin - administration & dosage Ovalbumin - immunology Pulmonary Eosinophilia - immunology Pulmonary Eosinophilia - prevention & control RNA, Messenger - biosynthesis TARC protein Th2 Cells - immunology Th2 Cells - metabolism Thymus Gland - immunology |
| title | Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice |
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