Induction of Hyporesponsiveness and Impaired T Lymphocyte Activation by the CD31 Receptor:Ligand Pathway in T Cells

CD31 is a member of the Ig superfamily expressed on various cell types of the vasculature, including a certain subpopulation of T lymphocytes. Previous reports suggest that interaction of CD31 with its heterophilic ligand on T cells (T cell CD31 ligand) plays a regulatory role in T lymphocyte activa...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-02, Vol.166 (4), p.2364-2371
Hauptverfasser:	Prager, Elisabeth, Staffler, Gunther, Majdic, Otto, Saemann, Marcus D, Godar, Samuel, Zlabinger, Gerhard J, Stockinger, Hannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Animals Antigens, CD Antigens, Differentiation - biosynthesis CD31 antigen CD31L protein CD4 Antigens - biosynthesis Cell Line CHO Cells Clonal Anergy - genetics Clone Cells Cricetinae CTLA-4 Antigen Cytokines - antagonists & inhibitors Cytokines - biosynthesis Down-Regulation - genetics Down-Regulation - immunology Gene Transfer Techniques Humans Immune Tolerance - genetics Immunoconjugates Immunosuppressive Agents - antagonists & inhibitors Immunosuppressive Agents - metabolism Immunosuppressive Agents - pharmacology Ligands Lymphocyte Activation - genetics Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis Platelet Endothelial Cell Adhesion Molecule-1 - blood Platelet Endothelial Cell Adhesion Molecule-1 - genetics Platelet Endothelial Cell Adhesion Molecule-1 - physiology Signal Transduction - genetics Signal Transduction - immunology T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Transduction, Genetic
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