[7alpha-18F]fluoro-17alpha-methyl-5alpha-dihydrotestosterone: a ligand for androgen receptor-mediated imaging of prostate cancer

We have synthesized a 18F-labeled androgen, [7alpha-18F]fluoro-17alpha-methyl-5alpha-dihydrotestosterone, in a no-carrier-added radiosynthesis by exchange of 18F- (tetrabutylammonium fluoride) with the 7beta-tosyloxy of 17alpha-methyl-5alpha-dihydrotestosterone. The nonradioactive steroid binds with...

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Veröffentlicht in:	Nuclear medicine and biology 2001-01, Vol.28 (1), p.85-90
Hauptverfasser:	Garg, P K, Labaree, D C, Hoyte, R M, Hochberg, R B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dihydrotestosterone - analogs & derivatives Dihydrotestosterone - chemical synthesis Dihydrotestosterone - chemistry Dihydrotestosterone - pharmacokinetics Male Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - metabolism Radionuclide Imaging Rats Receptors, Androgen - metabolism Tissue Distribution
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