AMP Deaminase Inhibitors. 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series

A highly potent AMP deaminase (AMPDA) inhibitor series was discovered by replacing the N3 substitutents of the two lead AMPDA inhibitor series with a conformationally restricted group. The most potent compound, 3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo[4,5-d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2001-02, Vol.44 (4), p.613-618
Hauptverfasser:	Kasibhatla, Srinivas Rao, Bookser, Brett C, Xiao, Wei, Erion, Mark D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - chemistry Adenosine Deaminase Inhibitors AMP Deaminase - antagonists & inhibitors AMP Deaminase - chemistry Analytical, structural and metabolic biochemistry Animals Azepines - chemical synthesis Azepines - chemistry Biological and medical sciences Cattle Drug Design Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Humans Hydrolases Imidazoles - chemical synthesis Imidazoles - chemistry Medical sciences Miscellaneous Pharmacology. Drug treatments Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!