Sulfated glycans and elevated temperature stimulate PrP(Sc)-dependent cell-free formation of protease-resistant prion protein

A conformational conversion of the normal, protease- sensitive prion protein (PrP-sen or PrP(C)) to a protease-resistant form (PrP-res or PrP(Sc)) is commonly thought to be required in transmissible spongiform encephalopathies (TSEs). Endogenous sulfated glycosaminoglycans are associated with PrP-re...

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Veröffentlicht in:	The EMBO journal 2001-02, Vol.20 (3), p.377-386
Hauptverfasser:	Wong, C, Xiong, L W, Horiuchi, M, Raymond, L, Wehrly, K, Chesebro, B, Caughey, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell-Free System Circular Dichroism Cricetinae Endopeptidases - metabolism Hot Temperature In Vitro Techniques Mice Pentosan Sulfuric Polyester - pharmacology Prion Diseases - etiology Prion Diseases - metabolism Prion Diseases - prevention & control Protein Conformation - drug effects PrPC Proteins - chemistry PrPC Proteins - metabolism PrPSc Proteins - chemistry PrPSc Proteins - metabolism
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