Differences in Ca(2+) signaling underlie age-specific effects of secretagogues on colonic Cl(-) transport

Taurodeoxycholic acid (TDC) stimulates Cl(-) transport in adult (AD), but not weanling (WN) and newborn (NB), rabbit colonic epithelial cells (colonocytes). The present study demonstrates that stimuli like neurotensin (NT) are also age specific and identifies the age-dependent signaling step. Bile a...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2001-03, Vol.280 (3), p.C646-C658
Hauptverfasser:	Venkatasubramanian, J, Selvaraj, N, Carlos, M, Skaluba, S, Rasenick, M M, Rao, M C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Biological Transport - drug effects Biological Transport - physiology Calcimycin - pharmacology Calcium - physiology Calcium Signaling - physiology Cells, Cultured Chlorides - metabolism Cholagogues and Choleretics - pharmacology Colon - cytology Colon - drug effects Colon - metabolism GTP-Binding Proteins - physiology Intracellular Membranes - physiology Ionophores - pharmacology Neurotensin - pharmacology Rabbits Taurochenodeoxycholic Acid - pharmacology Taurocholic Acid - pharmacology Taurodeoxycholic Acid - pharmacology Type C Phospholipases - metabolism
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