Transcriptional response to ionizing radiation in human radiation sensitive cell lines
Abstract Background and purpose Radiation is a common treatment of cancer, but some patients show severe side effects when exposed to small doses of radiation. The aim of this study was to explore the underlying cause of radiation sensitivity in a group of radiation sensitive patients. Materials and...
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| Veröffentlicht in: | Radiotherapy and oncology 2007-06, Vol.83 (3), p.256-260 |
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| container_title | Radiotherapy and oncology |
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| creator | Landmark, H Nahas, S.A Aarøe, J Gatti, R Børresen-Dale, A.-L Rødningen, O.K |
| description | Abstract Background and purpose Radiation is a common treatment of cancer, but some patients show severe side effects when exposed to small doses of radiation. The aim of this study was to explore the underlying cause of radiation sensitivity in a group of radiation sensitive patients. Materials and methods Lymphoblastoid cell lines from 5 normal individuals, 4 Ataxia Telangiectasia (AT), and 12 non-AT radiation sensitive (RS) patients were irradiated. RNA was isolated before and after radiation and hybridized to 15k cDNA microarrays and gene expression was recorded. Results and conclusion The RS cell lines showed an expression phenotype different from both the AT and normal cell lines. Six of the RS cell lines had a distinct expression profile before radiation. This implies that the RS patients are a heterogeneous group, but that six of the patients may have a common cause of radiation sensitivity. |
| doi_str_mv | 10.1016/j.radonc.2007.04.017 |
| format | Article |
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The aim of this study was to explore the underlying cause of radiation sensitivity in a group of radiation sensitive patients. Materials and methods Lymphoblastoid cell lines from 5 normal individuals, 4 Ataxia Telangiectasia (AT), and 12 non-AT radiation sensitive (RS) patients were irradiated. RNA was isolated before and after radiation and hybridized to 15k cDNA microarrays and gene expression was recorded. Results and conclusion The RS cell lines showed an expression phenotype different from both the AT and normal cell lines. Six of the RS cell lines had a distinct expression profile before radiation. This implies that the RS patients are a heterogeneous group, but that six of the patients may have a common cause of radiation sensitivity.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2007.04.017</identifier><identifier>PMID: 17512073</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Ataxia Telangiectasia - pathology ; Ataxia Telangiectasia Mutated Proteins ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Cell Line ; Cell Line, Tumor ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Gene expression ; Hematology, Oncology and Palliative Medicine ; Humans ; Protein-Serine-Threonine Kinases - genetics ; Protein-Serine-Threonine Kinases - metabolism ; Radiation sensitivity ; Radiation therapy ; Radiation Tolerance ; Radiation, Ionizing ; Reference Values ; RNA - biosynthesis ; Transcription, Genetic - radiation effects ; Tumor Suppressor Proteins - genetics ; Tumor Suppressor Proteins - metabolism</subject><ispartof>Radiotherapy and oncology, 2007-06, Vol.83 (3), p.256-260</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2007 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-3fc8d776ceb4774b66b44899f702044dfccda9efd1e385606be2804c32507a2f3</citedby><cites>FETCH-LOGICAL-c415t-3fc8d776ceb4774b66b44899f702044dfccda9efd1e385606be2804c32507a2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.radonc.2007.04.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17512073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Landmark, H</creatorcontrib><creatorcontrib>Nahas, S.A</creatorcontrib><creatorcontrib>Aarøe, J</creatorcontrib><creatorcontrib>Gatti, R</creatorcontrib><creatorcontrib>Børresen-Dale, A.-L</creatorcontrib><creatorcontrib>Rødningen, O.K</creatorcontrib><title>Transcriptional response to ionizing radiation in human radiation sensitive cell lines</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>Abstract Background and purpose Radiation is a common treatment of cancer, but some patients show severe side effects when exposed to small doses of radiation. The aim of this study was to explore the underlying cause of radiation sensitivity in a group of radiation sensitive patients. Materials and methods Lymphoblastoid cell lines from 5 normal individuals, 4 Ataxia Telangiectasia (AT), and 12 non-AT radiation sensitive (RS) patients were irradiated. RNA was isolated before and after radiation and hybridized to 15k cDNA microarrays and gene expression was recorded. Results and conclusion The RS cell lines showed an expression phenotype different from both the AT and normal cell lines. Six of the RS cell lines had a distinct expression profile before radiation. This implies that the RS patients are a heterogeneous group, but that six of the patients may have a common cause of radiation sensitivity.</description><subject>Ataxia Telangiectasia - pathology</subject><subject>Ataxia Telangiectasia Mutated Proteins</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Gene expression</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Protein-Serine-Threonine Kinases - metabolism</subject><subject>Radiation sensitivity</subject><subject>Radiation therapy</subject><subject>Radiation Tolerance</subject><subject>Radiation, Ionizing</subject><subject>Reference Values</subject><subject>RNA - biosynthesis</subject><subject>Transcription, Genetic - radiation effects</subject><subject>Tumor Suppressor Proteins - genetics</subject><subject>Tumor Suppressor Proteins - metabolism</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVpaTZpv0EpPvVmZ2RrPfYlUELzBwI9NM1VyPI40dYrbTV2IP30kdmFhlxyEgy_92b0nhBfJBQSZH26KaLpg7dFCYAFqAIkvhMr2WCbQ9Pge7FKGOaNVHAkjpk3AFBChR_FkcS1LAGrlbi7jcazjW43ueDNmEXiXfBM2RSyNHH_nL_P0iZnFiBzPnuYt8a_GDF5dpN7pMzSOGaj88SfxIfBjEyfD--J-H3x4_b8Kr_5eXl9_v0mt0qup7wabNMj1pY6hai6uu6Uatp2wHSpUv1gbW9aGnpJVbOuoe6obEDZqlwDmnKoTsS3ve8uhr8z8aS3jpczjKcws0aoK2yhTaDagzYG5kiD3kW3NfFJS9BLnnqj93nqJU8NSqc8k-zrwX_uttT_Fx0CTMDZHqD0y0dHUbN15C31LpKddB_cWxteG9iUoLNm_ENPxJswx1QLa6m51KB_LZ0ulQJCkiuongFMKp6f</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Landmark, H</creator><creator>Nahas, S.A</creator><creator>Aarøe, J</creator><creator>Gatti, R</creator><creator>Børresen-Dale, A.-L</creator><creator>Rødningen, O.K</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Transcriptional response to ionizing radiation in human radiation sensitive cell lines</title><author>Landmark, H ; Nahas, S.A ; Aarøe, J ; Gatti, R ; Børresen-Dale, A.-L ; Rødningen, O.K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-3fc8d776ceb4774b66b44899f702044dfccda9efd1e385606be2804c32507a2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Ataxia Telangiectasia - pathology</topic><topic>Ataxia Telangiectasia Mutated Proteins</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cell Line</topic><topic>Cell Line, Tumor</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Gene expression</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Protein-Serine-Threonine Kinases - metabolism</topic><topic>Radiation sensitivity</topic><topic>Radiation therapy</topic><topic>Radiation Tolerance</topic><topic>Radiation, Ionizing</topic><topic>Reference Values</topic><topic>RNA - biosynthesis</topic><topic>Transcription, Genetic - radiation effects</topic><topic>Tumor Suppressor Proteins - genetics</topic><topic>Tumor Suppressor Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Landmark, H</creatorcontrib><creatorcontrib>Nahas, S.A</creatorcontrib><creatorcontrib>Aarøe, J</creatorcontrib><creatorcontrib>Gatti, R</creatorcontrib><creatorcontrib>Børresen-Dale, A.-L</creatorcontrib><creatorcontrib>Rødningen, O.K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Landmark, H</au><au>Nahas, S.A</au><au>Aarøe, J</au><au>Gatti, R</au><au>Børresen-Dale, A.-L</au><au>Rødningen, O.K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptional response to ionizing radiation in human radiation sensitive cell lines</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>83</volume><issue>3</issue><spage>256</spage><epage>260</epage><pages>256-260</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>Abstract Background and purpose Radiation is a common treatment of cancer, but some patients show severe side effects when exposed to small doses of radiation. The aim of this study was to explore the underlying cause of radiation sensitivity in a group of radiation sensitive patients. Materials and methods Lymphoblastoid cell lines from 5 normal individuals, 4 Ataxia Telangiectasia (AT), and 12 non-AT radiation sensitive (RS) patients were irradiated. RNA was isolated before and after radiation and hybridized to 15k cDNA microarrays and gene expression was recorded. Results and conclusion The RS cell lines showed an expression phenotype different from both the AT and normal cell lines. Six of the RS cell lines had a distinct expression profile before radiation. This implies that the RS patients are a heterogeneous group, but that six of the patients may have a common cause of radiation sensitivity.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>17512073</pmid><doi>10.1016/j.radonc.2007.04.017</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Ataxia Telangiectasia - pathology Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Cell Line, Tumor DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene expression Hematology, Oncology and Palliative Medicine Humans Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Radiation sensitivity Radiation therapy Radiation Tolerance Radiation, Ionizing Reference Values RNA - biosynthesis Transcription, Genetic - radiation effects Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism |
| title | Transcriptional response to ionizing radiation in human radiation sensitive cell lines |
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