Sperm maturation in the epididymis: a new look at an old problem

The osmotic challenges facing maturing spermatozoa and their responses to them are discussed in relation to the concept of sperm maturation, defined as the increased ability of more distally recovered epididymal spermatozoa to fertilize eggs when inseminated into the female tract. One explanation co...

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Veröffentlicht in:Asian journal of andrology 2007-07, Vol.9 (4), p.533-539
1. Verfasser: Cooper, Trevor G.
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description The osmotic challenges facing maturing spermatozoa and their responses to them are discussed in relation to the concept of sperm maturation, defined as the increased ability of more distally recovered epididymal spermatozoa to fertilize eggs when inseminated into the female tract. One explanation could be that the more distal cells are better able to regulate their volume, and reach the oviducts, as a consequence of uptake of epididymal osmolytes. Increased motility, zona binding and oolemma fusion capacities are also acquired within the epididymis and are necessary for those cells that finally arrive at the site of fertilization.
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source MEDLINE; Wiley Journals; DOAJ Directory of Open Access Journals
subjects Animals
epididymal function
Epididymis - physiology
Female
fertilization
Fertilization - physiology
Humans
in vivo
Infertility, Male - physiopathology
Male
Mammals
Mice
osmotic challenge
Ovum - physiology
sperm maturation
Sperm Maturation - physiology
Spermatozoa - physiology
title Sperm maturation in the epididymis: a new look at an old problem
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