Sildenafil-mediated reduction in retinal function in heterozygous mice lacking the γ-subunit of phosphodiesterase

Retinitis pigmentosa (RP) is a common inherited degenerative retinal disease that has many causes including mutations in the genes coding for cyclic guanosine monophosphate (cGMP) phosphodiesterase 6 (PDE6). Sildenafil (Viagra; Pfizer Pharmaceuticals, New York, NY), a widely used medication for erec...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2001-02, Vol.42 (2), p.523-527
Hauptverfasser:	BEHN, Darren, POTTER, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-GMP Phosphodiesterases - antagonists & inhibitors 3',5'-Cyclic-GMP Phosphodiesterases - deficiency Animals Biological and medical sciences Cyclic Nucleotide Phosphodiesterases, Type 6 Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Electroretinography Female Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Pharmacology. Drug treatments Phosphodiesterase Inhibitors - pharmacology Piperazines - pharmacology Purines Retina - drug effects Retina - enzymology Retina - physiology Retinitis Pigmentosa - physiopathology Sildenafil Citrate Sulfones Toxicity: eye
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