Alpha-blockade downregulates myosin heavy chain gene expression in human benign prostatic hyperplasia

Objectives. Smooth muscle (SM), a major component of prostate stroma, plays an important role in the pathogenesis of benign prostatic hyperplasia. In many muscle systems, steroid hormones and alpha 1-adrenergic neurotransmitters tightly regulate expression of contractile proteins. In this study, SM...

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Veröffentlicht in:	Urology (Ridgewood, N.J.) N.J.), 2001, Vol.57 (1), p.170-175
Hauptverfasser:	Lin, Victor K, Benaim, Elie A, McConnell, John D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - therapeutic use Adult Aged Aged, 80 and over Analysis of Variance Androgen Antagonists - therapeutic use Biological and medical sciences Down-Regulation Gene Expression - drug effects Humans Male Medical sciences Middle Aged Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism Nephrology. Urinary tract diseases Prostate - metabolism Prostatic Hyperplasia - drug therapy Prostatic Hyperplasia - genetics Prostatic Hyperplasia - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Tumors of the urinary system Urinary tract. Prostate gland
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