Expression of vascular endothelial growth factor (VEGF) and VEGF receptor-1 (Flt-1) in Graves disease possibly correlated with increased vascular density

To evaluate the relation between hypervascularization and vascular endothelial growth factor (VEGF) in the thyroid glands of patients with Graves disease, 19 Graves disease tissues and 6 normal thyroid tissues were studied by immunohistochemistry, in situ hybridization (ISH), and reverse transcripta...

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Veröffentlicht in:	Human pathology 2001-01, Vol.32 (1), p.10-17
Hauptverfasser:	Nagura, Satoru, Katoh, Ryohei, Miyagi, Eri, Shibuya, Masabumi, Kawaoi, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Endocrinopathies Endothelial Growth Factors - analysis Endothelial Growth Factors - genetics Female flt-1 Gene Expression Regulation Graves disease Graves Disease - genetics Graves Disease - metabolism Graves Disease - pathology Humans In Situ Hybridization Lymphokines - analysis Lymphokines - genetics Male Medical sciences Middle Aged Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Non tumoral diseases. Target tissue resistance. Benign neoplasms Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - genetics Receptor Protein-Tyrosine Kinases - analysis Receptor Protein-Tyrosine Kinases - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Thyroid Gland - blood supply Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid. Thyroid axis (diseases) vascular density vascular endothelial growth factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factors
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