Glucocorticoids increase sodium pump alpha(2)- and beta(1)-subunit abundance and mRNA in rat skeletal muscle

Fourteen-day adrenal steroid treatment increases [(3)H]ouabain binding sites 22-48% in muscle biopsies from patients treated with adrenal steroids for chronic obstructive lung disease and in rats treated with dexamethasone (Dex). Ouabain binding measures plasma membrane sodium pumps (Na(+)-K(+)-ATPa...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2001-03, Vol.280 (3), p.C509-C516
Hauptverfasser:	Thompson, C B, Dorup, I, Ahn, J, Leong, P K, McDonough, A A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dexamethasone - pharmacology Female Glucocorticoids - pharmacology Isoenzymes - genetics Isoenzymes - metabolism Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Rats Rats, Wistar RNA, Messenger - metabolism Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism
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