Cutting Edge: Migration to Nonlymphoid Tissues Results in Functional Conversion of Central to Effector Memory CD8 T Cells
Memory CD8 T cells, essential for defense against intracellular pathogens, are heterogeneous with respect to phenotype and function. Constitutively lytic effector memory cells primarily reside in nonlymphoid tissues, whereas secondary lymphoid tissues contain functionally quiescent central memory ce...
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| Veröffentlicht in: | Journal of Immunology 2007-07, Vol.179 (1), p.36-40 |
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| container_title | Journal of Immunology |
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| creator | Marzo, Amanda L Yagita, Hideo Lefrancois, Leo |
| description | Memory CD8 T cells, essential for defense against intracellular pathogens, are heterogeneous with respect to phenotype and function. Constitutively lytic effector memory cells primarily reside in nonlymphoid tissues, whereas secondary lymphoid tissues contain functionally quiescent central memory cells. However, the mechanism by which functionally distinct memory populations are maintained is unknown. In this study, we show that resting CD8 memory cells modified their functional abilities upon entry into nonlymphoid tissues, as exemplified by the induction of granzyme B and lytic activity. Contemporaneously, the costimulator CD27 was down-regulated. These findings hold important implications for memory cell lineage development and tissue-specific immunity. |
| doi_str_mv | 10.4049/jimmunol.179.1.36 |
| format | Article |
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Constitutively lytic effector memory cells primarily reside in nonlymphoid tissues, whereas secondary lymphoid tissues contain functionally quiescent central memory cells. However, the mechanism by which functionally distinct memory populations are maintained is unknown. In this study, we show that resting CD8 memory cells modified their functional abilities upon entry into nonlymphoid tissues, as exemplified by the induction of granzyme B and lytic activity. Contemporaneously, the costimulator CD27 was down-regulated. These findings hold important implications for memory cell lineage development and tissue-specific immunity.</description><subject>Adoptive Transfer</subject><subject>Animals</subject><subject>CD8-Positive T-Lymphocytes - cytology</subject><subject>CD8-Positive T-Lymphocytes - enzymology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - transplantation</subject><subject>Cell Movement - immunology</subject><subject>Cytotoxicity, Immunologic</subject><subject>Down-Regulation - immunology</subject><subject>Granzymes - biosynthesis</subject><subject>Immunologic Memory</subject><subject>Immunophenotyping</subject><subject>Liver - cytology</subject><subject>Liver - immunology</subject><subject>Lung - cytology</subject><subject>Lung - immunology</subject><subject>Lymphoid Tissue - cytology</subject><subject>Lymphoid Tissue - immunology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Tumor Necrosis Factor Receptor Superfamily, Member 7 - biosynthesis</subject><subject>Up-Regulation - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGO0zAQhi0EYsvCA3BBvsAtxWM7dsINZbuAtAsSKmfLjZ3Wq8QutrNV3x5X7cKR00ij7_80ox-ht0CWnPD244ObptmHcQmyXcKSiWdoAXVNKiGIeI4WhFBagRTyCr1K6YEQIgjlL9EVyFq2BJoFOnZzzs5v8cps7Sd877ZRZxc8zgF_D348TvtdcAavXUqzTfinTfOYE3Ye386-P6F6xF3wjzamUy4MuLM-x7ItitUw2D6HiO_tFOIRdzcNXhdgHNNr9GLQY7JvLvMa_bpdrbuv1d2PL9-6z3dVzwnLFee1oLwHKofa8o3uwRIhqayt3RAD1DSat1II2OjBgBHAeN9ayhgx2srasGv04ezdx_C7vJDV5FJfLtDehjkpSQSjDaP_BaEVLTSCFxDOYB9DStEOah_dpONRAVGnYtRTMaoUo0AxUTLvLvJ5M1nzL3FpogDvz8DObXcHF61Kkx7HgoM6HA5_RX8Aj6qZXw</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Marzo, Amanda L</creator><creator>Yagita, Hideo</creator><creator>Lefrancois, Leo</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Cutting Edge: Migration to Nonlymphoid Tissues Results in Functional Conversion of Central to Effector Memory CD8 T Cells</title><author>Marzo, Amanda L ; 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| identifier | ISSN: 0022-1767 |
| ispartof | Journal of Immunology, 2007-07, Vol.179 (1), p.36-40 |
| issn | 0022-1767 1550-6606 1365-2567 |
| language | eng |
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| source | MEDLINE; Wiley Journals; Wiley Online Library Free Content; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adoptive Transfer Animals CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - transplantation Cell Movement - immunology Cytotoxicity, Immunologic Down-Regulation - immunology Granzymes - biosynthesis Immunologic Memory Immunophenotyping Liver - cytology Liver - immunology Lung - cytology Lung - immunology Lymphoid Tissue - cytology Lymphoid Tissue - immunology Mice Mice, Inbred C57BL Mice, Transgenic Tumor Necrosis Factor Receptor Superfamily, Member 7 - biosynthesis Up-Regulation - immunology |
| title | Cutting Edge: Migration to Nonlymphoid Tissues Results in Functional Conversion of Central to Effector Memory CD8 T Cells |
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