Clinical outcomes and fertility after conservative treatment of ovarian borderline tumors
Objective: To assess clinical outcome and fertility in patients treated conservatively for a low malignant potential (LMP) ovarian tumor. Design: Retrospective study. Setting: Gynecologic oncology department of a cancer care center in France. Patient(s): Forty-four patients treated with conservative...
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| Veröffentlicht in: | Fertility and sterility 2001, Vol.75 (1), p.92-96 |
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| creator | Morice, Philippe Camatte, Sophie El Hassan, Janah Pautier, Patricia Duvillard, Pierre Castaigne, Damienne |
| description | Objective: To assess clinical outcome and fertility in patients treated conservatively for a low malignant potential (LMP) ovarian tumor.
Design: Retrospective study.
Setting: Gynecologic oncology department of a cancer care center in France.
Patient(s): Forty-four patients treated with conservative management for a stage I (n = 32) or stage II or III (n = 12) LMP tumor.
Intervention(s): Thirty-three patients had unilateral adnexectomy and 11 had cystectomy. Cystectomy was bilateral in 1 patient and was done in conjunction with contralateral adnexectomy in 5 patients.
Main Outcome Measure(s): Tumor recurrence and pregnancy rates.
Result(s): Tumor recurrence rates after radical surgery (hysterectomy with bilateral salpingo-oophorectomy), adnexectomy, and cystectomy were 5.7%, 15.1%, and 36.3%, respectively (
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| doi_str_mv | 10.1016/S0015-0282(00)01633-2 |
| format | Article |
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Design: Retrospective study.
Setting: Gynecologic oncology department of a cancer care center in France.
Patient(s): Forty-four patients treated with conservative management for a stage I (n = 32) or stage II or III (n = 12) LMP tumor.
Intervention(s): Thirty-three patients had unilateral adnexectomy and 11 had cystectomy. Cystectomy was bilateral in 1 patient and was done in conjunction with contralateral adnexectomy in 5 patients.
Main Outcome Measure(s): Tumor recurrence and pregnancy rates.
Result(s): Tumor recurrence rates after radical surgery (hysterectomy with bilateral salpingo-oophorectomy), adnexectomy, and cystectomy were 5.7%, 15.1%, and 36.3%, respectively (
P<.01). Among patients who initially received conservative treatment, tumors did not recur in the form of invasive carcinoma. Five patients who had recurrence underwent repeated conservative management; these patients are alive and free of disease. Seventeen pregnancies (of which 15 were spontaneous) occurred in 14 patients; 13 pregnancies occurred in patients with stage I disease and 4 occurred in patients with stage III disease.
Conclusion(s): Conservative management of LMP tumor significantly increases the risk of recurrence but does not affect overall survival. Such management offers even patients with advanced disease the chance to have spontaneous pregnancy. Conservative management might be proposed in young patients who wish to preserve their fertility, but careful follow-up will be required to detect tumor recurrence.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(00)01633-2</identifier><identifier>PMID: 11163822</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>adnexectomy ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; borderline tumor ; cystectomy ; Female ; Female genital diseases ; Fertility - physiology ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - surgery ; Ovarian Neoplasms - therapy ; ovarian tumor ; Pregnancy ; Pregnancy Outcome ; Recurrence ; Survival ; Treatment Outcome ; Tumors</subject><ispartof>Fertility and sterility, 2001, Vol.75 (1), p.92-96</ispartof><rights>2001 American Society for Reproductive Medicine</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-3917854b5f1d08ddda6f7493bc23df9838e7d09484e03c5ff6a0cef7dfd5dfbe3</citedby><cites>FETCH-LOGICAL-c502t-3917854b5f1d08ddda6f7493bc23df9838e7d09484e03c5ff6a0cef7dfd5dfbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(00)01633-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=864068$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11163822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morice, Philippe</creatorcontrib><creatorcontrib>Camatte, Sophie</creatorcontrib><creatorcontrib>El Hassan, Janah</creatorcontrib><creatorcontrib>Pautier, Patricia</creatorcontrib><creatorcontrib>Duvillard, Pierre</creatorcontrib><creatorcontrib>Castaigne, Damienne</creatorcontrib><title>Clinical outcomes and fertility after conservative treatment of ovarian borderline tumors</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective: To assess clinical outcome and fertility in patients treated conservatively for a low malignant potential (LMP) ovarian tumor.
Design: Retrospective study.
Setting: Gynecologic oncology department of a cancer care center in France.
Patient(s): Forty-four patients treated with conservative management for a stage I (n = 32) or stage II or III (n = 12) LMP tumor.
Intervention(s): Thirty-three patients had unilateral adnexectomy and 11 had cystectomy. Cystectomy was bilateral in 1 patient and was done in conjunction with contralateral adnexectomy in 5 patients.
Main Outcome Measure(s): Tumor recurrence and pregnancy rates.
Result(s): Tumor recurrence rates after radical surgery (hysterectomy with bilateral salpingo-oophorectomy), adnexectomy, and cystectomy were 5.7%, 15.1%, and 36.3%, respectively (
P<.01). Among patients who initially received conservative treatment, tumors did not recur in the form of invasive carcinoma. Five patients who had recurrence underwent repeated conservative management; these patients are alive and free of disease. Seventeen pregnancies (of which 15 were spontaneous) occurred in 14 patients; 13 pregnancies occurred in patients with stage I disease and 4 occurred in patients with stage III disease.
Conclusion(s): Conservative management of LMP tumor significantly increases the risk of recurrence but does not affect overall survival. Such management offers even patients with advanced disease the chance to have spontaneous pregnancy. Conservative management might be proposed in young patients who wish to preserve their fertility, but careful follow-up will be required to detect tumor recurrence.</description><subject>adnexectomy</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>borderline tumor</subject><subject>cystectomy</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Fertility - physiology</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Ovarian Neoplasms - therapy</subject><subject>ovarian tumor</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Recurrence</subject><subject>Survival</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFrFTEQx4NY7LP6EZSAUPSwOkk22exJ5FG1UPCgHjyFbDKByO6mJtkH_famfY969DQw8_vPDD9CXjF4z4CpD98BmOyAa_4W4F3rCNHxJ2THpFSdVFI8JbtH5Jw8L-U3ACg28GfknLHGa8535Nd-jmt0dqZpqy4tWKhdPQ2Ya5xjvaM2VMzUpbVgPtgaD0hrRlsXXCtNgaaDzdGudErZY27L2nxbUi4vyFmwc8GXp3pBfn6--rH_2t18-3K9_3TTOQm8dmJkg5b9JAPzoL33VoWhH8XkuPBh1ELj4GHsdY8gnAxBWXAYBh-89GFCcUEuj3tvc_qzYalmicXhPNsV01bMAEpwGKGB8gi6nErJGMxtjovNd4aBuXdqHpyae2EGwDw4NbzlXp8ObNOC_l_qJLEBb06ALc1kyHZ1sTxyWvWgdKM-HilsMg4Rsyku4urQx4yuGp_ifx75C20qlMw</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Morice, Philippe</creator><creator>Camatte, Sophie</creator><creator>El Hassan, Janah</creator><creator>Pautier, Patricia</creator><creator>Duvillard, Pierre</creator><creator>Castaigne, Damienne</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Clinical outcomes and fertility after conservative treatment of ovarian borderline tumors</title><author>Morice, Philippe ; Camatte, Sophie ; El Hassan, Janah ; Pautier, Patricia ; Duvillard, Pierre ; Castaigne, Damienne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-3917854b5f1d08ddda6f7493bc23df9838e7d09484e03c5ff6a0cef7dfd5dfbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>adnexectomy</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>borderline tumor</topic><topic>cystectomy</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Fertility - physiology</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Ovarian Neoplasms - therapy</topic><topic>ovarian tumor</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Recurrence</topic><topic>Survival</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morice, Philippe</creatorcontrib><creatorcontrib>Camatte, Sophie</creatorcontrib><creatorcontrib>El Hassan, Janah</creatorcontrib><creatorcontrib>Pautier, Patricia</creatorcontrib><creatorcontrib>Duvillard, Pierre</creatorcontrib><creatorcontrib>Castaigne, Damienne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morice, Philippe</au><au>Camatte, Sophie</au><au>El Hassan, Janah</au><au>Pautier, Patricia</au><au>Duvillard, Pierre</au><au>Castaigne, Damienne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical outcomes and fertility after conservative treatment of ovarian borderline tumors</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2001</date><risdate>2001</risdate><volume>75</volume><issue>1</issue><spage>92</spage><epage>96</epage><pages>92-96</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective: To assess clinical outcome and fertility in patients treated conservatively for a low malignant potential (LMP) ovarian tumor.
Design: Retrospective study.
Setting: Gynecologic oncology department of a cancer care center in France.
Patient(s): Forty-four patients treated with conservative management for a stage I (n = 32) or stage II or III (n = 12) LMP tumor.
Intervention(s): Thirty-three patients had unilateral adnexectomy and 11 had cystectomy. Cystectomy was bilateral in 1 patient and was done in conjunction with contralateral adnexectomy in 5 patients.
Main Outcome Measure(s): Tumor recurrence and pregnancy rates.
Result(s): Tumor recurrence rates after radical surgery (hysterectomy with bilateral salpingo-oophorectomy), adnexectomy, and cystectomy were 5.7%, 15.1%, and 36.3%, respectively (
P<.01). Among patients who initially received conservative treatment, tumors did not recur in the form of invasive carcinoma. Five patients who had recurrence underwent repeated conservative management; these patients are alive and free of disease. Seventeen pregnancies (of which 15 were spontaneous) occurred in 14 patients; 13 pregnancies occurred in patients with stage I disease and 4 occurred in patients with stage III disease.
Conclusion(s): Conservative management of LMP tumor significantly increases the risk of recurrence but does not affect overall survival. Such management offers even patients with advanced disease the chance to have spontaneous pregnancy. Conservative management might be proposed in young patients who wish to preserve their fertility, but careful follow-up will be required to detect tumor recurrence.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11163822</pmid><doi>10.1016/S0015-0282(00)01633-2</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adnexectomy Adolescent Adult Aged Aged, 80 and over Biological and medical sciences borderline tumor cystectomy Female Female genital diseases Fertility - physiology Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Neoplasm Staging Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Ovarian Neoplasms - therapy ovarian tumor Pregnancy Pregnancy Outcome Recurrence Survival Treatment Outcome Tumors |
| title | Clinical outcomes and fertility after conservative treatment of ovarian borderline tumors |
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