Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus

Susceptibility to autoimmune hepatitis type I (AIH-1) has been associated with HLA-DR3, DR52, and DR4 antigens in Caucasian and Oriental patients. However, in Brazil, disease susceptibility is primarily linked to DR13 and DR52. In this highly admixed population, we find different DR13-associated hap...

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Veröffentlicht in:	Human immunology 2001-02, Vol.62 (2), p.165-169
Hauptverfasser:	Goldberg, Anna Carla, Bittencourt, Paulo L, Mougin, Bruno, Cançado, Eduardo L.R, Porta, Gilda, Carrilho, Flair, Kalil, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Motifs - genetics autoimmune hepatitis Brazil Genetic Markers - immunology Genetic Predisposition to Disease - genetics genetic susceptibility Haplotypes - immunology Hepatitis, Autoimmune - classification Hepatitis, Autoimmune - etiology Hepatitis, Autoimmune - genetics Hepatitis, Autoimmune - immunology histocompatibility locus HLA Histocompatibility Testing HLA Antigens - genetics HLA genes HLA-DQ alpha-Chains HLA-DQ Antigens - genetics HLA-DQ beta-Chains HLA-DR Antigens - genetics HLA-DRB1 Chains HLA-DRB3 Chains Humans peptide presentation
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