The Human Endoplasmic Reticulum Molecular Chaperone BiP Is an Autoantigen for Rheumatoid Arthritis and Prevents the Induction of Experimental Arthritis

Rheumatoid arthritis (RA) is the most common, crippling human autoimmune disease. Using Western blotting and tandem mass spectroscopy, we have identified the endoplasmic reticulum chaperone BiP, a 78-kDa glucose-regulated protein, as a possible autoantigen. It preferentially stimulated increased pro...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-02, Vol.166 (3), p.1492-1498
Hauptverfasser:	Corrigall, Valerie M, Bodman-Smith, Mark D, Fife, Mark S, Canas, Benito, Myers, Linda K, Wooley, Paul H, Soh, Cecilia, Staines, Norman A, Pappin, Darryl J. C, Berlo, Suzanne E, van Eden, Willem, van der Zee, Ruurd, Lanchbury, Jerry S, Panayi, Gabriel S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Arthritis, Experimental - etiology Arthritis, Experimental - immunology Arthritis, Experimental - prevention & control Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Autoantibodies - biosynthesis Autoantibodies - blood Autoantigens - blood Autoantigens - immunology Autoantigens - isolation & purification BiP protein Carrier Proteins - administration & dosage Carrier Proteins - immunology Endoplasmic Reticulum - immunology Female Heat-Shock Proteins Humans Immunization Schedule Injections, Intradermal Injections, Intravenous Lymphocyte Activation Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Middle Aged Molecular Chaperones - administration & dosage Molecular Chaperones - immunology Rats Rats, Inbred Lew Rats, Wistar Synovial Membrane - immunology Synovial Membrane - pathology T-Lymphocytes - immunology T-Lymphocytes - pathology Tumor Cells, Cultured
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