Inhibition of Geranylgeranylation Reduces Angiotensin II-Mediated Free Radical Production in Vascular Smooth Muscle Cells: Involvement of Angiotensin AT1 Receptor Expression and Rac1 GTPase

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) may exert pleiotropic effects on vascular cells independent of lowering plasma cholesterol. To elucidate the molecular mechanisms involved in these effects, we investigated the impact of statins on production of reactive oxygen spe...

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Veröffentlicht in:	Molecular pharmacology 2001-03, Vol.59 (3), p.646-654
Hauptverfasser:	Wassmann, S, Laufs, U, Bäumer, A T, Müller, K, Konkol, C, Sauer, H, Böhm, M, Nickenig, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - drug effects Angiotensin II - physiology Animals Atorvastatin Cells, Cultured Down-Regulation Free Radicals - metabolism Gene Expression - drug effects GTP Phosphohydrolases - physiology Heptanoic Acids - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Male Muscle, Smooth, Vascular - metabolism Protein Prenylation Pyrroles - pharmacology rac1 GTP-Binding Protein - antagonists & inhibitors rac1 GTP-Binding Protein - metabolism Radioligand Assay Rats Rats, Inbred SHR Rats, Sprague-Dawley Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Receptors, Angiotensin - biosynthesis Receptors, Angiotensin - genetics Receptors, Angiotensin - physiology RNA Stability - drug effects RNA, Messenger - drug effects RNA, Messenger - metabolism
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