N-terminal PDZ domain is required for NHERF dimerization

NHERF, a 55 kDa PDZ-containing protein, binds receptors and ion transporters to mediate signal transduction at the plasma membrane. Recombinant NHERF demonstrated an apparent size of 150 kDa on gel filtration, which could be reduced to approximately 55 kDa by protein denaturing agents, consistent wi...

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Veröffentlicht in:	FEBS letters 2001-02, Vol.489 (2), p.233-236
Hauptverfasser:	Shenolikar, Shirish, Minkoff, Charles M., Steplock, Deborah A., Evangelista, Christine, Liu, Min-Zhi, Weinman, Edward J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biosensing Techniques Cell Line Dimerization Na +/H + exchanger-3 Okadaic acid Peptide Fragments - metabolism Phosphoproteins - chemistry Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Protein Binding Protein oligomerization Protein phosphorylation Protein Structure, Tertiary PSD-95/Disc large/ZO-1 domain Rabbits Recombinant Proteins - chemistry Recombinant Proteins - metabolism Sodium-Hydrogen Exchangers
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