The changing pattern of diagnosis of infantile cholestasis
Objective: Cholestatic liver disease in infancy is caused by a wide range of conditions. This study reviews the pattern of diagnosis of infants with cholestasis presenting to a tertiary referral paediatric hospital in Sydney, Australia, during a 12‐year period (1985–96). Methodology: Infants aged le...
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| Veröffentlicht in: | Journal of paediatrics and child health 2001-02, Vol.37 (1), p.47-50 |
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| container_title | Journal of paediatrics and child health |
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| creator | Stormon, MO Dorney, SFA Kamath, KR O'Loughlin, EV Gaskin, KJ |
| description | Objective: Cholestatic liver disease in infancy is caused by a wide range of conditions. This study reviews the pattern of diagnosis of infants with cholestasis presenting to a tertiary referral paediatric hospital in Sydney, Australia, during a 12‐year period (1985–96).
Methodology: Infants aged less than 6 months with cholestasis were identified retrospectively from hospital records and data retrieved from the medical records.
Results: There were 205 infants identified as having cholestatic liver disease. The aetiology of the cholestasis was idiopathic in 25%, metabolic/genetic in 23%, and due to obstruction in 20%, parenteral nutrition in 20%, infection in 9% and bile duct hypoplasia in 3%.
Conclusions: This study highlights the changing patterns of diagnosis of cholestatic liver disease in infants at a tertiary paediatric facility, demonstrating that up to 50% of cases are now due to genetic/metabolic diseases or parenteral nutrition, and a high proportion are due to idiopathic disease. |
| doi_str_mv | 10.1046/j.1440-1754.2001.00613.x |
| format | Article |
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Methodology: Infants aged less than 6 months with cholestasis were identified retrospectively from hospital records and data retrieved from the medical records.
Results: There were 205 infants identified as having cholestatic liver disease. The aetiology of the cholestasis was idiopathic in 25%, metabolic/genetic in 23%, and due to obstruction in 20%, parenteral nutrition in 20%, infection in 9% and bile duct hypoplasia in 3%.
Conclusions: This study highlights the changing patterns of diagnosis of cholestatic liver disease in infants at a tertiary paediatric facility, demonstrating that up to 50% of cases are now due to genetic/metabolic diseases or parenteral nutrition, and a high proportion are due to idiopathic disease.</description><identifier>ISSN: 1034-4810</identifier><identifier>EISSN: 1440-1754</identifier><identifier>DOI: 10.1046/j.1440-1754.2001.00613.x</identifier><identifier>PMID: 11168869</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Age of Onset ; bile duct hypoplasia ; biliary obstruction ; cholestasis ; Cholestasis - epidemiology ; Cholestasis - etiology ; Female ; genetic metabolic disease ; Humans ; Infant ; Infant, Newborn ; Infection - complications ; liver disease ; Male ; Metabolism, Inborn Errors - complications ; neonatal ; New South Wales - epidemiology ; Parenteral Nutrition, Total - adverse effects ; Retrospective Studies</subject><ispartof>Journal of paediatrics and child health, 2001-02, Vol.37 (1), p.47-50</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4023-3384ad6f4cc9fa10e3d4845047dc94432b926275b3254feadae7425e3fa7059d3</citedby><cites>FETCH-LOGICAL-c4023-3384ad6f4cc9fa10e3d4845047dc94432b926275b3254feadae7425e3fa7059d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1440-1754.2001.00613.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1440-1754.2001.00613.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11168869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stormon, MO</creatorcontrib><creatorcontrib>Dorney, SFA</creatorcontrib><creatorcontrib>Kamath, KR</creatorcontrib><creatorcontrib>O'Loughlin, EV</creatorcontrib><creatorcontrib>Gaskin, KJ</creatorcontrib><title>The changing pattern of diagnosis of infantile cholestasis</title><title>Journal of paediatrics and child health</title><addtitle>J Paediatr Child Health</addtitle><description>Objective: Cholestatic liver disease in infancy is caused by a wide range of conditions. This study reviews the pattern of diagnosis of infants with cholestasis presenting to a tertiary referral paediatric hospital in Sydney, Australia, during a 12‐year period (1985–96).
Methodology: Infants aged less than 6 months with cholestasis were identified retrospectively from hospital records and data retrieved from the medical records.
Results: There were 205 infants identified as having cholestatic liver disease. The aetiology of the cholestasis was idiopathic in 25%, metabolic/genetic in 23%, and due to obstruction in 20%, parenteral nutrition in 20%, infection in 9% and bile duct hypoplasia in 3%.
Conclusions: This study highlights the changing patterns of diagnosis of cholestatic liver disease in infants at a tertiary paediatric facility, demonstrating that up to 50% of cases are now due to genetic/metabolic diseases or parenteral nutrition, and a high proportion are due to idiopathic disease.</description><subject>Age of Onset</subject><subject>bile duct hypoplasia</subject><subject>biliary obstruction</subject><subject>cholestasis</subject><subject>Cholestasis - epidemiology</subject><subject>Cholestasis - etiology</subject><subject>Female</subject><subject>genetic metabolic disease</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infection - complications</subject><subject>liver disease</subject><subject>Male</subject><subject>Metabolism, Inborn Errors - complications</subject><subject>neonatal</subject><subject>New South Wales - epidemiology</subject><subject>Parenteral Nutrition, Total - adverse effects</subject><subject>Retrospective Studies</subject><issn>1034-4810</issn><issn>1440-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFOwzAMhiMEYmPwCqgnbi1O46Qp4oImGKAxOAztGGVtunV07Wg6sb09KZ3gysm2_P229BHiUQgooLheBRQRfBpxDEIAGgAIyoLdEen_Lo5dDwx9lBR65MzaFQCEnMtT0qOUCilF3Cc306XxkqUuF3m58Da6aUxdelXmpblelJXNbTvkZabLJi9atCqMbbRbnJOTTBfWXBzqgLw_3E-Hj_74dfQ0vBv7CULIfMYk6lRkmCRxpikYlqJEDhilSYzIwnkcijDicxZyzIxOtYkw5IZlOgIep2xArrq7m7r63Lrnap3bxBSFLk21tSoCwSiT0oGyA5O6srY2mdrU-VrXe0VBtd7USrV6VKtHtd7Ujze1c9HLw4_tfG3Sv-BBlANuO-DLWdj_-7B6fhu6xsX9Lp7bxux-47r-UCJiEVezyUhNJzOcxKMXJdg3-0mJvg</recordid><startdate>200102</startdate><enddate>200102</enddate><creator>Stormon, MO</creator><creator>Dorney, SFA</creator><creator>Kamath, KR</creator><creator>O'Loughlin, EV</creator><creator>Gaskin, KJ</creator><general>Blackwell Science Pty</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200102</creationdate><title>The changing pattern of diagnosis of infantile cholestasis</title><author>Stormon, MO ; Dorney, SFA ; Kamath, KR ; O'Loughlin, EV ; Gaskin, KJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4023-3384ad6f4cc9fa10e3d4845047dc94432b926275b3254feadae7425e3fa7059d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age of Onset</topic><topic>bile duct hypoplasia</topic><topic>biliary obstruction</topic><topic>cholestasis</topic><topic>Cholestasis - epidemiology</topic><topic>Cholestasis - etiology</topic><topic>Female</topic><topic>genetic metabolic disease</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infection - complications</topic><topic>liver disease</topic><topic>Male</topic><topic>Metabolism, Inborn Errors - complications</topic><topic>neonatal</topic><topic>New South Wales - epidemiology</topic><topic>Parenteral Nutrition, Total - adverse effects</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stormon, MO</creatorcontrib><creatorcontrib>Dorney, SFA</creatorcontrib><creatorcontrib>Kamath, KR</creatorcontrib><creatorcontrib>O'Loughlin, EV</creatorcontrib><creatorcontrib>Gaskin, KJ</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of paediatrics and child health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stormon, MO</au><au>Dorney, SFA</au><au>Kamath, KR</au><au>O'Loughlin, EV</au><au>Gaskin, KJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The changing pattern of diagnosis of infantile cholestasis</atitle><jtitle>Journal of paediatrics and child health</jtitle><addtitle>J Paediatr Child Health</addtitle><date>2001-02</date><risdate>2001</risdate><volume>37</volume><issue>1</issue><spage>47</spage><epage>50</epage><pages>47-50</pages><issn>1034-4810</issn><eissn>1440-1754</eissn><abstract>Objective: Cholestatic liver disease in infancy is caused by a wide range of conditions. This study reviews the pattern of diagnosis of infants with cholestasis presenting to a tertiary referral paediatric hospital in Sydney, Australia, during a 12‐year period (1985–96).
Methodology: Infants aged less than 6 months with cholestasis were identified retrospectively from hospital records and data retrieved from the medical records.
Results: There were 205 infants identified as having cholestatic liver disease. The aetiology of the cholestasis was idiopathic in 25%, metabolic/genetic in 23%, and due to obstruction in 20%, parenteral nutrition in 20%, infection in 9% and bile duct hypoplasia in 3%.
Conclusions: This study highlights the changing patterns of diagnosis of cholestatic liver disease in infants at a tertiary paediatric facility, demonstrating that up to 50% of cases are now due to genetic/metabolic diseases or parenteral nutrition, and a high proportion are due to idiopathic disease.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>11168869</pmid><doi>10.1046/j.1440-1754.2001.00613.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of paediatrics and child health, 2001-02, Vol.37 (1), p.47-50 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Age of Onset bile duct hypoplasia biliary obstruction cholestasis Cholestasis - epidemiology Cholestasis - etiology Female genetic metabolic disease Humans Infant Infant, Newborn Infection - complications liver disease Male Metabolism, Inborn Errors - complications neonatal New South Wales - epidemiology Parenteral Nutrition, Total - adverse effects Retrospective Studies |
| title | The changing pattern of diagnosis of infantile cholestasis |
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