Role of endocytosis in mediating downregulation of G-protein-coupled receptors

Many G-protein-coupled receptors (GPCRs) undergo agonist-induced endocytosis. Such endocytosis has been implicated in diverse processes of receptor regulation, including reversible sequestration of receptors in endosomes and proteolytic downregulation of receptors in lysosomes. The precise relations...

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Veröffentlicht in:	Trends in Pharmacological Sciences 2001-02, Vol.22 (2), p.91-96
Hauptverfasser:	Tsao, Patricia, Cao, Tracy, von Zastrow, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenoceptors Animals Clathrin-coated pits Down-Regulation - genetics Down-Regulation - physiology Endocytosis - physiology GPCR GTP-Binding Proteins - biosynthesis Humans Lysosomes Membrane trafficking PDZ-domain Signal Transduction - genetics
Online-Zugang:	Volltext
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