Discovery of a Novel Member of the Histamine Receptor Family

We report the discovery, tissue distribution and pharmacological characterization of a novel receptor, which we have named H4. Like the three histamine receptors reported previously (H1, H2, and H3), the H4 receptor is a G protein-coupled receptor and is most closely related to the H3 receptor, shar...

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Veröffentlicht in:	Molecular pharmacology 2001-03, Vol.59 (3), p.427-433
Hauptverfasser:	Nguyen, T, Shapiro, D A, George, S R, Setola, V, Lee, D K, Cheng, R, Rauser, L, Lee, S P, Lynch, K R, Roth, B L, O'Dowd, B F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amitriptyline - pharmacology Antidepressive Agents, Tricyclic - pharmacology Antipsychotic Agents - pharmacology Chlorpromazine - pharmacology Dose-Response Relationship, Drug Histamine - metabolism Humans Membrane Proteins - genetics Membrane Proteins - metabolism Models, Molecular Molecular Sequence Data Molecular Weight Radioligand Assay Receptors, G-Protein-Coupled Receptors, Histamine - drug effects Receptors, Histamine - genetics Receptors, Histamine - metabolism Receptors, Histamine H3 - chemistry Receptors, Histamine H4 Sequence Homology, Amino Acid Tissue Distribution
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