Insect resistance management for Syngenta’s VipCot™ transgenic cotton
Syngenta is seeking commercial registration for VipCot™ cotton, a pyramided transgenic cotton trait that expresses two insecticidal proteins derived from Bacillus thuringiensis Vip3A and Cry1Ab. Both proteins are highly effective against two key cotton pests, Helicoverpa zea cotton bollworm; and Hel...
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| Veröffentlicht in: | Journal of invertebrate pathology 2007-07, Vol.95 (3), p.227-230 |
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| creator | Kurtz, Ryan W. McCaffery, Alan O’Reilly, David |
| description | Syngenta is seeking commercial registration for VipCot™ cotton, a pyramided transgenic cotton trait that expresses two insecticidal proteins derived from
Bacillus thuringiensis Vip3A and Cry1Ab. Both proteins are highly effective against two key cotton pests,
Helicoverpa zea cotton bollworm; and
Heliothis virescens, tobacco budworm. To investigate the role of VipCot™ cotton in delaying the development of resistance in these pests to transgenic Bt traits, Syngenta has performed studies to determine the dose of proteins expressed in VipCot™ and evaluate the potential for cross-resistance between the component proteins. Following United States Environmental Protection Agency (US EPA) high dose methods 1 and 4, VipCot™ was shown to express a high dose of proteins for
H. zea and
H. virescens. VipCot™ was also confirmed to express a high dose of proteins for
H. zea through US EPA Method 5. Additionally, all the data collected to date verify a lack of cross-resistance between Vip3A and Cry proteins. These two key pieces of information indicate that VipCot™ cotton should be very durable under the currently mandated high dose plus refuge insect resistance management strategy. |
| doi_str_mv | 10.1016/j.jip.2007.03.014 |
| format | Article |
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Bacillus thuringiensis Vip3A and Cry1Ab. Both proteins are highly effective against two key cotton pests,
Helicoverpa zea cotton bollworm; and
Heliothis virescens, tobacco budworm. To investigate the role of VipCot™ cotton in delaying the development of resistance in these pests to transgenic Bt traits, Syngenta has performed studies to determine the dose of proteins expressed in VipCot™ and evaluate the potential for cross-resistance between the component proteins. Following United States Environmental Protection Agency (US EPA) high dose methods 1 and 4, VipCot™ was shown to express a high dose of proteins for
H. zea and
H. virescens. VipCot™ was also confirmed to express a high dose of proteins for
H. zea through US EPA Method 5. Additionally, all the data collected to date verify a lack of cross-resistance between Vip3A and Cry proteins. These two key pieces of information indicate that VipCot™ cotton should be very durable under the currently mandated high dose plus refuge insect resistance management strategy.</description><identifier>ISSN: 0022-2011</identifier><identifier>EISSN: 1096-0805</identifier><identifier>DOI: 10.1016/j.jip.2007.03.014</identifier><identifier>PMID: 17475274</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Bacillus thuringiensis ; Bacterial Proteins - pharmacology ; Bacterial Toxins - pharmacology ; Bt cotton ; Bt resistance ; cotton ; cross resistance ; Cry1Ab protein ; crystal proteins ; Dose-Response Relationship, Immunologic ; Endotoxins - pharmacology ; Gossypium ; Gossypium - genetics ; Gossypium - microbiology ; Helicoverpa zea ; Heliothis virescens ; Hemolysin Proteins - pharmacology ; high protein dose ; Insect resistance management ; insecticidal proteins ; Insecticide Resistance - drug effects ; Insecticide Resistance - genetics ; Larva - drug effects ; Larva - growth & development ; Lepidoptera - drug effects ; Lepidoptera - genetics ; Plants, Genetically Modified ; protein synthesis ; resistance management ; transgenic plants ; Vip3A ; Vip3A protein ; Zea</subject><ispartof>Journal of invertebrate pathology, 2007-07, Vol.95 (3), p.227-230</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-5afe8b205811a774b1ad8daa669df69242531dfca5f3624ea012ae5d494747893</citedby><cites>FETCH-LOGICAL-c406t-5afe8b205811a774b1ad8daa669df69242531dfca5f3624ea012ae5d494747893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022201107000687$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17475274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kurtz, Ryan W.</creatorcontrib><creatorcontrib>McCaffery, Alan</creatorcontrib><creatorcontrib>O’Reilly, David</creatorcontrib><title>Insect resistance management for Syngenta’s VipCot™ transgenic cotton</title><title>Journal of invertebrate pathology</title><addtitle>J Invertebr Pathol</addtitle><description>Syngenta is seeking commercial registration for VipCot™ cotton, a pyramided transgenic cotton trait that expresses two insecticidal proteins derived from
Bacillus thuringiensis Vip3A and Cry1Ab. Both proteins are highly effective against two key cotton pests,
Helicoverpa zea cotton bollworm; and
Heliothis virescens, tobacco budworm. To investigate the role of VipCot™ cotton in delaying the development of resistance in these pests to transgenic Bt traits, Syngenta has performed studies to determine the dose of proteins expressed in VipCot™ and evaluate the potential for cross-resistance between the component proteins. Following United States Environmental Protection Agency (US EPA) high dose methods 1 and 4, VipCot™ was shown to express a high dose of proteins for
H. zea and
H. virescens. VipCot™ was also confirmed to express a high dose of proteins for
H. zea through US EPA Method 5. Additionally, all the data collected to date verify a lack of cross-resistance between Vip3A and Cry proteins. These two key pieces of information indicate that VipCot™ cotton should be very durable under the currently mandated high dose plus refuge insect resistance management strategy.</description><subject>Animals</subject><subject>Bacillus thuringiensis</subject><subject>Bacterial Proteins - pharmacology</subject><subject>Bacterial Toxins - pharmacology</subject><subject>Bt cotton</subject><subject>Bt resistance</subject><subject>cotton</subject><subject>cross resistance</subject><subject>Cry1Ab protein</subject><subject>crystal proteins</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Endotoxins - pharmacology</subject><subject>Gossypium</subject><subject>Gossypium - genetics</subject><subject>Gossypium - microbiology</subject><subject>Helicoverpa zea</subject><subject>Heliothis virescens</subject><subject>Hemolysin Proteins - pharmacology</subject><subject>high protein dose</subject><subject>Insect resistance management</subject><subject>insecticidal proteins</subject><subject>Insecticide Resistance - drug effects</subject><subject>Insecticide Resistance - genetics</subject><subject>Larva - drug effects</subject><subject>Larva - growth & development</subject><subject>Lepidoptera - drug effects</subject><subject>Lepidoptera - genetics</subject><subject>Plants, Genetically Modified</subject><subject>protein synthesis</subject><subject>resistance management</subject><subject>transgenic plants</subject><subject>Vip3A</subject><subject>Vip3A protein</subject><subject>Zea</subject><issn>0022-2011</issn><issn>1096-0805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGO0zAQhi0EYsvCA3CBnLglzDiOk4gTqliotBKHZblaU2dSuWriYrsr7Y0DL8GVR9snWVetxA1OHsnf_Jr5RojXCBUC6vfbauv2lQRoK6grQPVELBB6XUIHzVOxAJCylIB4IV7EuIVcNbp_Li6wVW0jW7UQq9Uc2aYicHQx0Wy5mGimDU88p2L0obi5nze5poefv2Px3e2XPj38-lOkQHPMH84W1qfk55fi2Ui7yK_O76W4vfr0bfmlvP76ebX8eF1aBTqVDY3crSU0HSK1rVojDd1ApHU_jLqXSjY1DqOlZqy1VEyAkrgZVK_y0F1fX4p3p9x98D8OHJOZXLS829HM_hBNC1q2ssf_gpgTMdMZxBNog48x8Gj2wU0U7g2COYo2W5NFm6NoA7XJonPPm3P4YT3x8LfjbDYDb0_ASN7QJrhobm_yLeoc0nVSHhf5cCI427pzHEy0jvMFBhfySczg3T8GeAThwpja</recordid><startdate>20070701</startdate><enddate>20070701</enddate><creator>Kurtz, Ryan W.</creator><creator>McCaffery, Alan</creator><creator>O’Reilly, David</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7SS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070701</creationdate><title>Insect resistance management for Syngenta’s VipCot™ transgenic cotton</title><author>Kurtz, Ryan W. ; McCaffery, Alan ; O’Reilly, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-5afe8b205811a774b1ad8daa669df69242531dfca5f3624ea012ae5d494747893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Bacillus thuringiensis</topic><topic>Bacterial Proteins - pharmacology</topic><topic>Bacterial Toxins - pharmacology</topic><topic>Bt cotton</topic><topic>Bt resistance</topic><topic>cotton</topic><topic>cross resistance</topic><topic>Cry1Ab protein</topic><topic>crystal proteins</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Endotoxins - pharmacology</topic><topic>Gossypium</topic><topic>Gossypium - genetics</topic><topic>Gossypium - microbiology</topic><topic>Helicoverpa zea</topic><topic>Heliothis virescens</topic><topic>Hemolysin Proteins - pharmacology</topic><topic>high protein dose</topic><topic>Insect resistance management</topic><topic>insecticidal proteins</topic><topic>Insecticide Resistance - drug effects</topic><topic>Insecticide Resistance - genetics</topic><topic>Larva - drug effects</topic><topic>Larva - growth & development</topic><topic>Lepidoptera - drug effects</topic><topic>Lepidoptera - genetics</topic><topic>Plants, Genetically Modified</topic><topic>protein synthesis</topic><topic>resistance management</topic><topic>transgenic plants</topic><topic>Vip3A</topic><topic>Vip3A protein</topic><topic>Zea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurtz, Ryan W.</creatorcontrib><creatorcontrib>McCaffery, Alan</creatorcontrib><creatorcontrib>O’Reilly, David</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of invertebrate pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurtz, Ryan W.</au><au>McCaffery, Alan</au><au>O’Reilly, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insect resistance management for Syngenta’s VipCot™ transgenic cotton</atitle><jtitle>Journal of invertebrate pathology</jtitle><addtitle>J Invertebr Pathol</addtitle><date>2007-07-01</date><risdate>2007</risdate><volume>95</volume><issue>3</issue><spage>227</spage><epage>230</epage><pages>227-230</pages><issn>0022-2011</issn><eissn>1096-0805</eissn><abstract>Syngenta is seeking commercial registration for VipCot™ cotton, a pyramided transgenic cotton trait that expresses two insecticidal proteins derived from
Bacillus thuringiensis Vip3A and Cry1Ab. Both proteins are highly effective against two key cotton pests,
Helicoverpa zea cotton bollworm; and
Heliothis virescens, tobacco budworm. To investigate the role of VipCot™ cotton in delaying the development of resistance in these pests to transgenic Bt traits, Syngenta has performed studies to determine the dose of proteins expressed in VipCot™ and evaluate the potential for cross-resistance between the component proteins. Following United States Environmental Protection Agency (US EPA) high dose methods 1 and 4, VipCot™ was shown to express a high dose of proteins for
H. zea and
H. virescens. VipCot™ was also confirmed to express a high dose of proteins for
H. zea through US EPA Method 5. Additionally, all the data collected to date verify a lack of cross-resistance between Vip3A and Cry proteins. These two key pieces of information indicate that VipCot™ cotton should be very durable under the currently mandated high dose plus refuge insect resistance management strategy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17475274</pmid><doi>10.1016/j.jip.2007.03.014</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Bacillus thuringiensis Bacterial Proteins - pharmacology Bacterial Toxins - pharmacology Bt cotton Bt resistance cotton cross resistance Cry1Ab protein crystal proteins Dose-Response Relationship, Immunologic Endotoxins - pharmacology Gossypium Gossypium - genetics Gossypium - microbiology Helicoverpa zea Heliothis virescens Hemolysin Proteins - pharmacology high protein dose Insect resistance management insecticidal proteins Insecticide Resistance - drug effects Insecticide Resistance - genetics Larva - drug effects Larva - growth & development Lepidoptera - drug effects Lepidoptera - genetics Plants, Genetically Modified protein synthesis resistance management transgenic plants Vip3A Vip3A protein Zea |
| title | Insect resistance management for Syngenta’s VipCot™ transgenic cotton |
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