The p38 mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts

The induction of interleukin-6 (IL-6), using a proinflammatory cytokine (tumor necrosis factor-α), was studied in a human osteoblast cell line (MG-63) in relation to p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB transcription factor. When added to MG-63 cells, tumor necrosis...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2001, Vol.28 (1), p.45-53
Hauptverfasser:	Chae, H.J, Chae, S.W, Chin, H.Y, Bang, B.G, Cho, S.B, Han, K.S, Kim, S.C, Tae, K.C, Lee, K.H, Kim, D.E, Im, M.K, Lee, S.J, Chang, J.Y, Lee, Y.M, Kim, H.M, Kim, H.H, Lee, Z.H, Kim, H.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants - pharmacology Biological and medical sciences Cells, Cultured Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Humans Imidazoles - pharmacology Interleukin-6 (IL-6) Interleukin-6 - biosynthesis Interleukin-6 - metabolism MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-κB inhibitor Nuclear factor (NF)-κB Osteoblast Osteoblasts - cytology Osteoblasts - enzymology Osteocalcin - metabolism p38 mitogen-activated protein kinase (MAPK) p38 Mitogen-Activated Protein Kinases Peptides - pharmacology Pyridines - pharmacology Pyrrolidines - pharmacology Skeleton and joints Thiocarbamates - pharmacology Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-α (TNF-α) Vertebrates: osteoarticular system, musculoskeletal system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!