In vitro and in vivo antibacterial evaluation of DRF 8417, a new oxazolidinone

Objectives and methods DRF 8417, a novel oxazolidinone, has been evaluated against Gram-positive and fastidious Gram-negative bacteria. In vitro activity of DRF 8417 was determined by broth microdilution method and in vivo efficacy studies were carried out in different murine systemic infection mode...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2007-07, Vol.60 (1), p.159-161
Hauptverfasser:	Sreenivas, K., Amarnath, P. V. S., Mallik, A., Sarnaik, H., Kumar, N. Selva, Takhi, M., Trehan, S., Kumar, M. Sitaram, Iqbal, J., Rajagopalan, R., Chakrabarti, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria beta-Lactam Resistance beta-Lactamases - metabolism Biological and medical sciences clinical isolates Disease Models, Animal Female Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - microbiology Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - microbiology Gram-Positive Cocci - drug effects Haemophilus Infections - drug therapy Haemophilus Infections - microbiology Haemophilus influenzae Haemophilus influenzae - drug effects Haemophilus influenzae - enzymology Humans Infections linezolid Male Medical research Medical sciences Mice Microbial Sensitivity Tests Microbiology Moraxella (Branhamella) catarrhalis - drug effects Moraxella catarrhalis Moraxellaceae Infections - drug therapy Moraxellaceae Infections - microbiology Oxazolidinones - chemistry Oxazolidinones - pharmacology Oxazolidinones - therapeutic use Pharmacology. Drug treatments Rodents Specific Pathogen-Free Organisms systemic infection models Treatment Outcome
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