Prolactin signaling to pim-1 expression: a role for phosphatidylinositol 3-kinase

Sublines of the lactogen-dependent, rat pre-T Nb2 lymphoma are useful as a model for the investigation of prolactin (PRL) signaling mechanisms, regulation of transcription of target genes, and the immunomodulatory and anti-apoptotic actions of the hormone in T lymphocytes. In the present study, coup...

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Veröffentlicht in:	Journal of neuroimmunology 2001-02, Vol.113 (2), p.249-259
Hauptverfasser:	Krumenacker, Joshua S, Narang, Vishal S, Buckley, Donna J, Buckley, Arthur R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division - drug effects Enzyme Inhibitors - pharmacology Jak2 protein Janus Kinase 2 Mitogen-Activated Protein Kinases - antagonists & inhibitors Nb2 Lymphoma Phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - physiology Phosphotransferases - antagonists & inhibitors pim-1 pim-1 gene Prolactin Prolactin - physiology Protein-Serine-Threonine Kinases Protein-Tyrosine Kinases - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-pim-1 Rats Signal Transduction - physiology Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - pathology ZAP-70 Protein-Tyrosine Kinase
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