Mitogen-Induced p53 Downregulation Precedes Vascular Smooth Muscle Cell Migration From Healthy Tunica Media and Proliferation

Abstract —The tumor suppressor protein p53 plays an important role in the cell-cycle G1 and G2 checkpoints. In response to DNA damage, p53 can induce the transcription of p21, which inhibits the activation of various G1 cyclin/cyclin-dependent kinase complexes. It is not known whether p53 plays a ro...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2001-02, Vol.21 (2), p.214-219
Hauptverfasser:	Rodríguez-Campos, Antonio, Ruiz-Enríquez, Pilar, Faraudo, Susanna, Badimon, Lina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis - metabolism Arteriosclerosis - physiopathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Movement - physiology Disease Models, Animal Down-Regulation - drug effects Genes, p53 - drug effects Genes, p53 - physiology Medical sciences Mitogens - pharmacology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Swine Tunica Media - cytology Tunica Media - physiopathology
Online-Zugang:	Volltext
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