Oxidative stress and haemodialysis: role of inflammation and duration of dialysis treatment
Background. Oxidative stress has long been demonstrated in haemodialysis patients. However, the factors influencing their oxidative status have not been characterized extensively in these patients. Therefore, the present study was designed to investigate the influence of a large number of factors kn...
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| Veröffentlicht in: | Nephrology, dialysis, transplantation dialysis, transplantation, 2001-02, Vol.16 (2), p.335-340 |
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| creator | Nguyen‐Khoa, Thao Massy, Ziad A. De Bandt, Jean Pascal Kebede, Messeret Salama, Lucie Lambrey, Guy Witko‐Sarsat, Véronique Drüeke, Tilman B. Lacour, Bernard Thévenin, Marc |
| description | Background. Oxidative stress has long been demonstrated in haemodialysis patients. However, the factors influencing their oxidative status have not been characterized extensively in these patients. Therefore, the present study was designed to investigate the influence of a large number of factors known to be associated with oxidative stress. Methods. In the present cross‐sectional study, we determined the plasma levels of lipid and protein oxidation markers in 31 non‐smoking haemodialysis patients and 18 non‐smoking healthy subjects, together with various components of the antioxidant system at the plasma and erythrocyte level. Results. No influence of age, diabetes or iron overload on oxidative markers and plasma and erythrocyte antioxidant systems was detected in these haemodialysis patients. The lack of an association between iron overload and oxidative status may be related to the lower level of plasma ascorbate in haemodialysis patients, since ascorbate favours the generation of free iron from ferritin‐bound iron. Interestingly, plasma C reactive protein (CRP) levels measured by highly sensitive CRP assay were correlated positively with plasma levels of thiobarbituric acid reactive substances (r=0.38, P |
| doi_str_mv | 10.1093/ndt/16.2.335 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70622884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70622884</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-5fcfb657814cc2f12b35aab65a119edc7a351cd28e24d45b64a6ac2a36adf4023</originalsourceid><addsrcrecordid>eNpF0EtPFEEUBeAKgcCI7FyTTkhc2UPdena7U6IDgYTEjMHgonKnHqG0H1jVY5h_b-mMsKrcOl_O4hDyBugcaMvPBzedg5qzOedyj8xAKFoz3sh9Misx1FTS9oi8yvkHpbRlWh-SIwCQjaDtjHy_fYoOp_jbV3lKPucKB1c9oO9HF7Hb5JjfV2nsfDWGKg6hw74vfBz-ObdO26OE_3lVanDq_TC9JgcBu-xPdu8x-fr50_Lisr65XVxdfLiprYB2qmWwYaWkbkBYywKwFZeI5QcBWu-sRi7BOtZ4JpyQKyVQoWXIFbogKOPH5O229zGNv9Y-T6aP2fquw8GP62w0VYw1jSjw3RbaNOacfDCPKfaYNgao-TumKWMaUIaZMmbhp7ve9ar37gXv1ivgbAcwW-xCwsHG_Owa1Wqtiqq3KubJPz2nmH4apbmW5vLbvVkull8-3t1dG-B_ACS_jb4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70622884</pqid></control><display><type>article</type><title>Oxidative stress and haemodialysis: role of inflammation and duration of dialysis treatment</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Nguyen‐Khoa, Thao ; Massy, Ziad A. ; De Bandt, Jean Pascal ; Kebede, Messeret ; Salama, Lucie ; Lambrey, Guy ; Witko‐Sarsat, Véronique ; Drüeke, Tilman B. ; Lacour, Bernard ; Thévenin, Marc</creator><creatorcontrib>Nguyen‐Khoa, Thao ; Massy, Ziad A. ; De Bandt, Jean Pascal ; Kebede, Messeret ; Salama, Lucie ; Lambrey, Guy ; Witko‐Sarsat, Véronique ; Drüeke, Tilman B. ; Lacour, Bernard ; Thévenin, Marc</creatorcontrib><description>Background. Oxidative stress has long been demonstrated in haemodialysis patients. However, the factors influencing their oxidative status have not been characterized extensively in these patients. Therefore, the present study was designed to investigate the influence of a large number of factors known to be associated with oxidative stress. Methods. In the present cross‐sectional study, we determined the plasma levels of lipid and protein oxidation markers in 31 non‐smoking haemodialysis patients and 18 non‐smoking healthy subjects, together with various components of the antioxidant system at the plasma and erythrocyte level. Results. No influence of age, diabetes or iron overload on oxidative markers and plasma and erythrocyte antioxidant systems was detected in these haemodialysis patients. The lack of an association between iron overload and oxidative status may be related to the lower level of plasma ascorbate in haemodialysis patients, since ascorbate favours the generation of free iron from ferritin‐bound iron. Interestingly, plasma C reactive protein (CRP) levels measured by highly sensitive CRP assay were correlated positively with plasma levels of thiobarbituric acid reactive substances (r=0.38, P<0.04) and negatively with plasma α‐tocopherol levels (r=−0.46, P<0.01). Moreover, significant inverse correlations were observed between duration of dialysis treatment and plasma levels of α‐tocopherol (r=−0.49, P<0.02) and ubiquinol (r=−0.40, P<0.05). Conclusions. Our results suggest that inflammatory status and duration of dialysis treatment are the most important factors relating to oxidative stress in haemodialysis patients.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/16.2.335</identifier><identifier>PMID: 11158409</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; advanced oxidation protein products (AOPP) ; Aged ; Aged, 80 and over ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Biomarkers ; C-Reactive Protein - analysis ; Emergency and intensive care: renal failure. Dialysis management ; Female ; glutathione ; haemodialysis ; highly sensitive C reactive protein assay ; Humans ; inflammation ; Inflammation - physiopathology ; Intensive care medicine ; Lipid Metabolism ; Male ; Medical sciences ; Middle Aged ; Oxidation-Reduction ; Oxidative Stress ; Oxidoreductases - metabolism ; Proteins - metabolism ; Renal Dialysis - adverse effects ; Time Factors ; vitamins</subject><ispartof>Nephrology, dialysis, transplantation, 2001-02, Vol.16 (2), p.335-340</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-5fcfb657814cc2f12b35aab65a119edc7a351cd28e24d45b64a6ac2a36adf4023</citedby><cites>FETCH-LOGICAL-c419t-5fcfb657814cc2f12b35aab65a119edc7a351cd28e24d45b64a6ac2a36adf4023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=869776$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11158409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen‐Khoa, Thao</creatorcontrib><creatorcontrib>Massy, Ziad A.</creatorcontrib><creatorcontrib>De Bandt, Jean Pascal</creatorcontrib><creatorcontrib>Kebede, Messeret</creatorcontrib><creatorcontrib>Salama, Lucie</creatorcontrib><creatorcontrib>Lambrey, Guy</creatorcontrib><creatorcontrib>Witko‐Sarsat, Véronique</creatorcontrib><creatorcontrib>Drüeke, Tilman B.</creatorcontrib><creatorcontrib>Lacour, Bernard</creatorcontrib><creatorcontrib>Thévenin, Marc</creatorcontrib><title>Oxidative stress and haemodialysis: role of inflammation and duration of dialysis treatment</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol. Dial. Transplant</addtitle><description>Background. Oxidative stress has long been demonstrated in haemodialysis patients. However, the factors influencing their oxidative status have not been characterized extensively in these patients. Therefore, the present study was designed to investigate the influence of a large number of factors known to be associated with oxidative stress. Methods. In the present cross‐sectional study, we determined the plasma levels of lipid and protein oxidation markers in 31 non‐smoking haemodialysis patients and 18 non‐smoking healthy subjects, together with various components of the antioxidant system at the plasma and erythrocyte level. Results. No influence of age, diabetes or iron overload on oxidative markers and plasma and erythrocyte antioxidant systems was detected in these haemodialysis patients. The lack of an association between iron overload and oxidative status may be related to the lower level of plasma ascorbate in haemodialysis patients, since ascorbate favours the generation of free iron from ferritin‐bound iron. Interestingly, plasma C reactive protein (CRP) levels measured by highly sensitive CRP assay were correlated positively with plasma levels of thiobarbituric acid reactive substances (r=0.38, P<0.04) and negatively with plasma α‐tocopherol levels (r=−0.46, P<0.01). Moreover, significant inverse correlations were observed between duration of dialysis treatment and plasma levels of α‐tocopherol (r=−0.49, P<0.02) and ubiquinol (r=−0.40, P<0.05). Conclusions. Our results suggest that inflammatory status and duration of dialysis treatment are the most important factors relating to oxidative stress in haemodialysis patients.</description><subject>Adult</subject><subject>advanced oxidation protein products (AOPP)</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>C-Reactive Protein - analysis</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>glutathione</subject><subject>haemodialysis</subject><subject>highly sensitive C reactive protein assay</subject><subject>Humans</subject><subject>inflammation</subject><subject>Inflammation - physiopathology</subject><subject>Intensive care medicine</subject><subject>Lipid Metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Oxidoreductases - metabolism</subject><subject>Proteins - metabolism</subject><subject>Renal Dialysis - adverse effects</subject><subject>Time Factors</subject><subject>vitamins</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EtPFEEUBeAKgcCI7FyTTkhc2UPdena7U6IDgYTEjMHgonKnHqG0H1jVY5h_b-mMsKrcOl_O4hDyBugcaMvPBzedg5qzOedyj8xAKFoz3sh9Misx1FTS9oi8yvkHpbRlWh-SIwCQjaDtjHy_fYoOp_jbV3lKPucKB1c9oO9HF7Hb5JjfV2nsfDWGKg6hw74vfBz-ObdO26OE_3lVanDq_TC9JgcBu-xPdu8x-fr50_Lisr65XVxdfLiprYB2qmWwYaWkbkBYywKwFZeI5QcBWu-sRi7BOtZ4JpyQKyVQoWXIFbogKOPH5O229zGNv9Y-T6aP2fquw8GP62w0VYw1jSjw3RbaNOacfDCPKfaYNgao-TumKWMaUIaZMmbhp7ve9ar37gXv1ivgbAcwW-xCwsHG_Owa1Wqtiqq3KubJPz2nmH4apbmW5vLbvVkull8-3t1dG-B_ACS_jb4</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Nguyen‐Khoa, Thao</creator><creator>Massy, Ziad A.</creator><creator>De Bandt, Jean Pascal</creator><creator>Kebede, Messeret</creator><creator>Salama, Lucie</creator><creator>Lambrey, Guy</creator><creator>Witko‐Sarsat, Véronique</creator><creator>Drüeke, Tilman B.</creator><creator>Lacour, Bernard</creator><creator>Thévenin, Marc</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>Oxidative stress and haemodialysis: role of inflammation and duration of dialysis treatment</title><author>Nguyen‐Khoa, Thao ; Massy, Ziad A. ; De Bandt, Jean Pascal ; Kebede, Messeret ; Salama, Lucie ; Lambrey, Guy ; Witko‐Sarsat, Véronique ; Drüeke, Tilman B. ; Lacour, Bernard ; Thévenin, Marc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-5fcfb657814cc2f12b35aab65a119edc7a351cd28e24d45b64a6ac2a36adf4023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>advanced oxidation protein products (AOPP)</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>C-Reactive Protein - analysis</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>glutathione</topic><topic>haemodialysis</topic><topic>highly sensitive C reactive protein assay</topic><topic>Humans</topic><topic>inflammation</topic><topic>Inflammation - physiopathology</topic><topic>Intensive care medicine</topic><topic>Lipid Metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Oxidoreductases - metabolism</topic><topic>Proteins - metabolism</topic><topic>Renal Dialysis - adverse effects</topic><topic>Time Factors</topic><topic>vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen‐Khoa, Thao</creatorcontrib><creatorcontrib>Massy, Ziad A.</creatorcontrib><creatorcontrib>De Bandt, Jean Pascal</creatorcontrib><creatorcontrib>Kebede, Messeret</creatorcontrib><creatorcontrib>Salama, Lucie</creatorcontrib><creatorcontrib>Lambrey, Guy</creatorcontrib><creatorcontrib>Witko‐Sarsat, Véronique</creatorcontrib><creatorcontrib>Drüeke, Tilman B.</creatorcontrib><creatorcontrib>Lacour, Bernard</creatorcontrib><creatorcontrib>Thévenin, Marc</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen‐Khoa, Thao</au><au>Massy, Ziad A.</au><au>De Bandt, Jean Pascal</au><au>Kebede, Messeret</au><au>Salama, Lucie</au><au>Lambrey, Guy</au><au>Witko‐Sarsat, Véronique</au><au>Drüeke, Tilman B.</au><au>Lacour, Bernard</au><au>Thévenin, Marc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress and haemodialysis: role of inflammation and duration of dialysis treatment</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol. Dial. Transplant</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>16</volume><issue>2</issue><spage>335</spage><epage>340</epage><pages>335-340</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Oxidative stress has long been demonstrated in haemodialysis patients. However, the factors influencing their oxidative status have not been characterized extensively in these patients. Therefore, the present study was designed to investigate the influence of a large number of factors known to be associated with oxidative stress. Methods. In the present cross‐sectional study, we determined the plasma levels of lipid and protein oxidation markers in 31 non‐smoking haemodialysis patients and 18 non‐smoking healthy subjects, together with various components of the antioxidant system at the plasma and erythrocyte level. Results. No influence of age, diabetes or iron overload on oxidative markers and plasma and erythrocyte antioxidant systems was detected in these haemodialysis patients. The lack of an association between iron overload and oxidative status may be related to the lower level of plasma ascorbate in haemodialysis patients, since ascorbate favours the generation of free iron from ferritin‐bound iron. Interestingly, plasma C reactive protein (CRP) levels measured by highly sensitive CRP assay were correlated positively with plasma levels of thiobarbituric acid reactive substances (r=0.38, P<0.04) and negatively with plasma α‐tocopherol levels (r=−0.46, P<0.01). Moreover, significant inverse correlations were observed between duration of dialysis treatment and plasma levels of α‐tocopherol (r=−0.49, P<0.02) and ubiquinol (r=−0.40, P<0.05). Conclusions. Our results suggest that inflammatory status and duration of dialysis treatment are the most important factors relating to oxidative stress in haemodialysis patients.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11158409</pmid><doi>10.1093/ndt/16.2.335</doi><tpages>6</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult advanced oxidation protein products (AOPP) Aged Aged, 80 and over Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers C-Reactive Protein - analysis Emergency and intensive care: renal failure. Dialysis management Female glutathione haemodialysis highly sensitive C reactive protein assay Humans inflammation Inflammation - physiopathology Intensive care medicine Lipid Metabolism Male Medical sciences Middle Aged Oxidation-Reduction Oxidative Stress Oxidoreductases - metabolism Proteins - metabolism Renal Dialysis - adverse effects Time Factors vitamins |
| title | Oxidative stress and haemodialysis: role of inflammation and duration of dialysis treatment |
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