Hepatitis B Virus X Protein Activates Transcription by Bypassing CREB Phosphorylation, Not by Stabilizing bZIP−DNA Complexes

Although previous work has shown that the hepatitis B virus X protein (pX) stabilizes complexes between basic region leucine zipper (bZIP) proteins and target DNA, the relationship between enhanced binding and transcriptional activation has not been established. Here we show that interactions betwee...

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Veröffentlicht in:	Biochemistry (Easton) 2001-01, Vol.40 (3), p.693-703
Hauptverfasser:	Pflum, Mary Kay H, Schneider, Tanya L, Hall, David, Schepartz, Alanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 2 Animals Basic-Leucine Zipper Transcription Factors CREB protein Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism G-Box Binding Factors HeLa Cells Hepatitis B virus Hepatitis B virus - physiology Humans Phosphorylation Promoter Regions, Genetic Protein Binding - genetics Rats Response Elements Trans-Activators - metabolism Trans-Activators - physiology Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation X protein
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