Stromal biology of pancreatic cancer

The genetic paradigm of cancer, focused largely on sequential molecular aberrations and associated biological impact in the neoplastic cell compartment of malignant tumors, has dominated our view of cancer pathogenesis. For the most part, this conceptualization has overlooked the dynamic and complex...

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Veröffentlicht in:	Journal of cellular biochemistry 2007-07, Vol.101 (4), p.887-907
Hauptverfasser:	Chu, Gerald C., Kimmelman, Alec C., Hezel, Aram F., DePinho, Ronald A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell Transformation, Neoplastic - metabolism Cyclooxygenase 2 - metabolism Humans Models, Biological NF-kappa B - metabolism pancreatic cancer pancreatic ductal adenocarcinoma Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Stromal Cells - metabolism Stromal Cells - pathology tumor microenvironment tumor stroma
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