Salmonella Pathogenicity Island 4 encodes a giant non-fimbrial adhesin and the cognate type 1 secretion system

Pathogenicity Islands play a major role in the pathogenesis of infections by Salmonella enterica. The molecular function of Salmonella Pathogenicity Island 4 (SPI4) is largely unknown, but recent work indicated a role of SPI4 for Salmonella pathogenesis in certain animal models. We analysed the viru...

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Veröffentlicht in:	Cellular microbiology 2007-07, Vol.9 (7), p.1834-1850
Hauptverfasser:	Gerlach, Roman G, Jäckel, Daniela, Stecher, Bärbel, Wagner, Carolin, Lupas, Andrei, Hardt, Wolf-Dietrich, Hensel, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - genetics Adhesins, Bacterial - metabolism Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins - secretion Caco-2 Cells Cell Line Colitis - microbiology Genomic Islands HeLa Cells Humans Intestinal Mucosa - microbiology Macrophages Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Rabbits Salmonella enterica Salmonella Infections, Animal - microbiology Salmonella typhimurium - genetics Salmonella typhimurium - metabolism Salmonella typhimurium - pathogenicity Virulence Factors
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