Follow-up study of intrahost HIV type 2 variability reveals discontinuous evolution of C2V3 sequences
Sequence change dynamics in the highly polymorphic C2V3 region of the envelope glycoprotein gp105 coding sequence of HIV-2 was studied for two HIV-2 seropositive Guinean individuals over a 5-year period. Proviral DNA was amplified by PCR from uncultured peripheral blood mononuclear cells (PBMC), clo...
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| Veröffentlicht in: | AIDS research and human retroviruses 2001-02, Vol.17 (3), p.253-256 |
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| container_title | AIDS research and human retroviruses |
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| creator | ESTEVES, Aida PIEDADE, Joao SANTOS, Candida VENENNO, Teresa CANAS-FERREIRA, Wanda F PARREIRA, Ricardo |
| description | Sequence change dynamics in the highly polymorphic C2V3 region of the envelope glycoprotein gp105 coding sequence of HIV-2 was studied for two HIV-2 seropositive Guinean individuals over a 5-year period. Proviral DNA was amplified by PCR from uncultured peripheral blood mononuclear cells (PBMC), cloned, and sequenced. Amino acid sequence alignment and phylogenetic analysis showed distinct viral populations for the three collected samples (1992, 1995, and 1997) for both individuals. A discontinuous replacement of sequences suggests activation of latent viruses present in reservoirs, a process that has been documented for the HIV-1 infection but unreported so far for HIV-2. The nucleotide sequences presented in this work have been assigned accession numbers AJ400276 to AJ400319. |
| doi_str_mv | 10.1089/088922201750063179 |
| format | Article |
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Proviral DNA was amplified by PCR from uncultured peripheral blood mononuclear cells (PBMC), cloned, and sequenced. Amino acid sequence alignment and phylogenetic analysis showed distinct viral populations for the three collected samples (1992, 1995, and 1997) for both individuals. A discontinuous replacement of sequences suggests activation of latent viruses present in reservoirs, a process that has been documented for the HIV-1 infection but unreported so far for HIV-2. 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Psychology ; Gene Products, env - chemistry ; Gene Products, env - genetics ; Genes, env - genetics ; Genetic Variation - genetics ; glycoprotein gp105 ; HIV Envelope Protein gp120 - genetics ; HIV Infections - virology ; HIV-2 - classification ; HIV-2 - genetics ; Human immunodeficiency virus 2 ; Humans ; Immunodeficiencies ; Immunodeficiencies. 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Proviral DNA was amplified by PCR from uncultured peripheral blood mononuclear cells (PBMC), cloned, and sequenced. Amino acid sequence alignment and phylogenetic analysis showed distinct viral populations for the three collected samples (1992, 1995, and 1997) for both individuals. A discontinuous replacement of sequences suggests activation of latent viruses present in reservoirs, a process that has been documented for the HIV-1 infection but unreported so far for HIV-2. The nucleotide sequences presented in this work have been assigned accession numbers AJ400276 to AJ400319.</description><subject>AIDS/HIV</subject><subject>Amino Acid Sequence</subject><subject>Biological and medical sciences</subject><subject>DNA, Viral - analysis</subject><subject>env Gene Products, Human Immunodeficiency Virus</subject><subject>env protein (C2V3 region)</subject><subject>Epidemiology</subject><subject>Evolution, Molecular</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Products, env - chemistry</subject><subject>Gene Products, env - genetics</subject><subject>Genes, env - genetics</subject><subject>Genetic Variation - genetics</subject><subject>glycoprotein gp105</subject><subject>HIV Envelope Protein gp120 - genetics</subject><subject>HIV Infections - virology</subject><subject>HIV-2 - classification</subject><subject>HIV-2 - genetics</subject><subject>Human immunodeficiency virus 2</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Peptide Fragments - genetics</subject><subject>Phylogeny</subject><subject>Proviruses</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>Virology</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0T1vFDEQBmALgciR8AcokBvolow_1y7RiZBIkWiStCvveiyM9taH7T10_x6fclIKCio3z_t6NEPIBwZfGBh7DcZYzjmwXgFowXr7imyYFawzEtRrsjmBrgl7Qd6V8gsAmldvyQVjrO8lmA3BmzTP6U-37mmpqz_SFGhcanY_U6n09u6J1uMeKacHl6Mb4xzrkWY8oJsL9bFMaalxWdNaKB7SvNaYllPHlj8JWvD3isuE5Yq8CS2A78_vJXm8-fawve3uf3y_23697yahoXZejDYEJSxab_gorPYKJA8CtQ0alAzj6IR0Gr0a-wm810p5Cdpzo7VCcUk-P_fuc2pflzrs2og4z27BNuLQg277Muq_kPWGSW5kg_wZTjmVkjEM-xx3Lh8HBsPpCsO_V2ihj-f2ddyhf4mc197ApzNwZXJzyG6ZYnlxkmlhFIi_wguPXQ</recordid><startdate>20010210</startdate><enddate>20010210</enddate><creator>ESTEVES, Aida</creator><creator>PIEDADE, Joao</creator><creator>SANTOS, Candida</creator><creator>VENENNO, Teresa</creator><creator>CANAS-FERREIRA, Wanda F</creator><creator>PARREIRA, Ricardo</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010210</creationdate><title>Follow-up study of intrahost HIV type 2 variability reveals discontinuous evolution of C2V3 sequences</title><author>ESTEVES, Aida ; PIEDADE, Joao ; SANTOS, Candida ; VENENNO, Teresa ; CANAS-FERREIRA, Wanda F ; PARREIRA, Ricardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-d3b9ff539e9d82b396d5042f3e69f6054fbba34a6ed5b7c0dd655d406d28665e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>AIDS/HIV</topic><topic>Amino Acid Sequence</topic><topic>Biological and medical sciences</topic><topic>DNA, Viral - analysis</topic><topic>env Gene Products, Human Immunodeficiency Virus</topic><topic>env protein (C2V3 region)</topic><topic>Epidemiology</topic><topic>Evolution, Molecular</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Products, env - chemistry</topic><topic>Gene Products, env - genetics</topic><topic>Genes, env - genetics</topic><topic>Genetic Variation - genetics</topic><topic>glycoprotein gp105</topic><topic>HIV Envelope Protein gp120 - genetics</topic><topic>HIV Infections - virology</topic><topic>HIV-2 - classification</topic><topic>HIV-2 - genetics</topic><topic>Human immunodeficiency virus 2</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Peptide Fragments - genetics</topic><topic>Phylogeny</topic><topic>Proviruses</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ESTEVES, Aida</creatorcontrib><creatorcontrib>PIEDADE, Joao</creatorcontrib><creatorcontrib>SANTOS, Candida</creatorcontrib><creatorcontrib>VENENNO, Teresa</creatorcontrib><creatorcontrib>CANAS-FERREIRA, Wanda F</creatorcontrib><creatorcontrib>PARREIRA, Ricardo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ESTEVES, Aida</au><au>PIEDADE, Joao</au><au>SANTOS, Candida</au><au>VENENNO, Teresa</au><au>CANAS-FERREIRA, Wanda F</au><au>PARREIRA, Ricardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follow-up study of intrahost HIV type 2 variability reveals discontinuous evolution of C2V3 sequences</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2001-02-10</date><risdate>2001</risdate><volume>17</volume><issue>3</issue><spage>253</spage><epage>256</epage><pages>253-256</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>Sequence change dynamics in the highly polymorphic C2V3 region of the envelope glycoprotein gp105 coding sequence of HIV-2 was studied for two HIV-2 seropositive Guinean individuals over a 5-year period. Proviral DNA was amplified by PCR from uncultured peripheral blood mononuclear cells (PBMC), cloned, and sequenced. Amino acid sequence alignment and phylogenetic analysis showed distinct viral populations for the three collected samples (1992, 1995, and 1997) for both individuals. A discontinuous replacement of sequences suggests activation of latent viruses present in reservoirs, a process that has been documented for the HIV-1 infection but unreported so far for HIV-2. The nucleotide sequences presented in this work have been assigned accession numbers AJ400276 to AJ400319.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>11177408</pmid><doi>10.1089/088922201750063179</doi><tpages>4</tpages></addata></record> |
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| ispartof | AIDS research and human retroviruses, 2001-02, Vol.17 (3), p.253-256 |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS/HIV Amino Acid Sequence Biological and medical sciences DNA, Viral - analysis env Gene Products, Human Immunodeficiency Virus env protein (C2V3 region) Epidemiology Evolution, Molecular Fundamental and applied biological sciences. Psychology Gene Products, env - chemistry Gene Products, env - genetics Genes, env - genetics Genetic Variation - genetics glycoprotein gp105 HIV Envelope Protein gp120 - genetics HIV Infections - virology HIV-2 - classification HIV-2 - genetics Human immunodeficiency virus 2 Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Medical sciences Microbiology Molecular Sequence Data Peptide Fragments - genetics Phylogeny Proviruses Sequence Alignment Sequence Analysis, DNA Virology |
| title | Follow-up study of intrahost HIV type 2 variability reveals discontinuous evolution of C2V3 sequences |
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