Mice with a Targeted Disruption of the H1t Gene Are Fertile and Undergo Normal Changes in Structural Chromosomal Proteins During Spermiogenesis

H1t is an H1 histone variant unique to late spermatocytes and early spermatids. Using gene targeting and embryonic stem cell technologies, we have produced mice with a disrupted H1t gene. Homozygous H1t -null mice have normal fertility and show no obvious phenotypic consequence due to the lack of th...

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