Goldmann Applanation Tonometry in the Conscious Rat
To determine whether the Goldmann applanation tonometer can be modified to measure intraocular pressure (IOP) in the conscious rat. In anesthetized rats Goldmann tonometers were tested that had reduced biprism angles in the applanating tips and reduced weights in the tonometer body from those used i...
Gespeichert in:
| Veröffentlicht in: | Investigative ophthalmology & visual science 2001-02, Vol.42 (2), p.340-342 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 342 |
|---|---|
| container_issue | 2 |
| container_start_page | 340 |
| container_title | Investigative ophthalmology & visual science |
| container_volume | 42 |
| creator | Cohan, Bruce E Bohr, David F |
| description | To determine whether the Goldmann applanation tonometer can be modified to measure intraocular pressure (IOP) in the conscious rat.
In anesthetized rats Goldmann tonometers were tested that had reduced biprism angles in the applanating tips and reduced weights in the tonometer body from those used in humans and species with similar size eyes. Tonometers with tips with biprism angles of 48 degrees and an applied weight of 25 mg per Goldmann scale division (2 g full scale) were calibrated for the rat against manometrically measured IOP. Tonometers, thus modified, were then used in conscious, unsedated rats.
In conscious rats the measured mean Goldmann value was 15.5 +/- 0.6 mm Hg (confidence interval = 14.1, 16.6 mm Hg). This was the plateau level reached after the repeated applanations (approximately 10) required to eliminate an artifactual decline in initial Goldmann readings, which was larger than that in humans.
The Goldmann applanation tonometer was modified to measure IOP in the conscious, unsedated rat. This instrument, the standard for measuring this key physiological parameter in the human eye, can now be applied to the laboratory rat. This may advance the use of this important animal as a model in IOP and glaucoma research. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70620673</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70620673</sourcerecordid><originalsourceid>FETCH-LOGICAL-h180t-8db27a89663737de8750e47b829c52a29f6e84a1b45b87fb1a6bbb973abdf4aa3</originalsourceid><addsrcrecordid>eNo9z11LwzAYBeAgipvTvyAF0btCvpNejqFTGAgyr8ObNrWRNqlNR9m_t7Dp1bl5OJxzgZZECJoLpdklWmLCZY455gt0k9I3xpQQiq_RghAyE8mXiG1jW3UQQrbu-xYCjD6GbB9D7Nw4HDMfsrFx2SaGVPp4SNkHjLfoqoY2ubtzrtDny_N-85rv3rdvm_Uub4jGY64rSxXoQkqmmKqcVgI7rqymRSko0KKWTnMglgurVW0JSGttoRjYquYAbIWeTr39EH8OLo2m86l07TzTzVOMwpJiqdgM78_wYDtXmX7wHQxH83dzBg9nAKmEth4glD79u4JyUehZPZ5U47-ayQ_OpA7adi4lZpomTg01jGP2C4HhaA0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70620673</pqid></control><display><type>article</type><title>Goldmann Applanation Tonometry in the Conscious Rat</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Cohan, Bruce E ; Bohr, David F</creator><creatorcontrib>Cohan, Bruce E ; Bohr, David F</creatorcontrib><description>To determine whether the Goldmann applanation tonometer can be modified to measure intraocular pressure (IOP) in the conscious rat.
In anesthetized rats Goldmann tonometers were tested that had reduced biprism angles in the applanating tips and reduced weights in the tonometer body from those used in humans and species with similar size eyes. Tonometers with tips with biprism angles of 48 degrees and an applied weight of 25 mg per Goldmann scale division (2 g full scale) were calibrated for the rat against manometrically measured IOP. Tonometers, thus modified, were then used in conscious, unsedated rats.
In conscious rats the measured mean Goldmann value was 15.5 +/- 0.6 mm Hg (confidence interval = 14.1, 16.6 mm Hg). This was the plateau level reached after the repeated applanations (approximately 10) required to eliminate an artifactual decline in initial Goldmann readings, which was larger than that in humans.
The Goldmann applanation tonometer was modified to measure IOP in the conscious, unsedated rat. This instrument, the standard for measuring this key physiological parameter in the human eye, can now be applied to the laboratory rat. This may advance the use of this important animal as a model in IOP and glaucoma research.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 11157864</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Animals ; Biological and medical sciences ; Calibration ; Consciousness ; Glaucoma and intraocular pressure ; Intraocular Pressure ; Medical sciences ; Ophthalmology ; Rats ; Rats, Inbred BN ; Tonometry, Ocular - methods</subject><ispartof>Investigative ophthalmology & visual science, 2001-02, Vol.42 (2), p.340-342</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=924598$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11157864$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohan, Bruce E</creatorcontrib><creatorcontrib>Bohr, David F</creatorcontrib><title>Goldmann Applanation Tonometry in the Conscious Rat</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To determine whether the Goldmann applanation tonometer can be modified to measure intraocular pressure (IOP) in the conscious rat.
In anesthetized rats Goldmann tonometers were tested that had reduced biprism angles in the applanating tips and reduced weights in the tonometer body from those used in humans and species with similar size eyes. Tonometers with tips with biprism angles of 48 degrees and an applied weight of 25 mg per Goldmann scale division (2 g full scale) were calibrated for the rat against manometrically measured IOP. Tonometers, thus modified, were then used in conscious, unsedated rats.
In conscious rats the measured mean Goldmann value was 15.5 +/- 0.6 mm Hg (confidence interval = 14.1, 16.6 mm Hg). This was the plateau level reached after the repeated applanations (approximately 10) required to eliminate an artifactual decline in initial Goldmann readings, which was larger than that in humans.
The Goldmann applanation tonometer was modified to measure IOP in the conscious, unsedated rat. This instrument, the standard for measuring this key physiological parameter in the human eye, can now be applied to the laboratory rat. This may advance the use of this important animal as a model in IOP and glaucoma research.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calibration</subject><subject>Consciousness</subject><subject>Glaucoma and intraocular pressure</subject><subject>Intraocular Pressure</subject><subject>Medical sciences</subject><subject>Ophthalmology</subject><subject>Rats</subject><subject>Rats, Inbred BN</subject><subject>Tonometry, Ocular - methods</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9z11LwzAYBeAgipvTvyAF0btCvpNejqFTGAgyr8ObNrWRNqlNR9m_t7Dp1bl5OJxzgZZECJoLpdklWmLCZY455gt0k9I3xpQQiq_RghAyE8mXiG1jW3UQQrbu-xYCjD6GbB9D7Nw4HDMfsrFx2SaGVPp4SNkHjLfoqoY2ubtzrtDny_N-85rv3rdvm_Uub4jGY64rSxXoQkqmmKqcVgI7rqymRSko0KKWTnMglgurVW0JSGttoRjYquYAbIWeTr39EH8OLo2m86l07TzTzVOMwpJiqdgM78_wYDtXmX7wHQxH83dzBg9nAKmEth4glD79u4JyUehZPZ5U47-ayQ_OpA7adi4lZpomTg01jGP2C4HhaA0</recordid><startdate>200102</startdate><enddate>200102</enddate><creator>Cohan, Bruce E</creator><creator>Bohr, David F</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200102</creationdate><title>Goldmann Applanation Tonometry in the Conscious Rat</title><author>Cohan, Bruce E ; Bohr, David F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h180t-8db27a89663737de8750e47b829c52a29f6e84a1b45b87fb1a6bbb973abdf4aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calibration</topic><topic>Consciousness</topic><topic>Glaucoma and intraocular pressure</topic><topic>Intraocular Pressure</topic><topic>Medical sciences</topic><topic>Ophthalmology</topic><topic>Rats</topic><topic>Rats, Inbred BN</topic><topic>Tonometry, Ocular - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohan, Bruce E</creatorcontrib><creatorcontrib>Bohr, David F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohan, Bruce E</au><au>Bohr, David F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Goldmann Applanation Tonometry in the Conscious Rat</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2001-02</date><risdate>2001</risdate><volume>42</volume><issue>2</issue><spage>340</spage><epage>342</epage><pages>340-342</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>To determine whether the Goldmann applanation tonometer can be modified to measure intraocular pressure (IOP) in the conscious rat.
In anesthetized rats Goldmann tonometers were tested that had reduced biprism angles in the applanating tips and reduced weights in the tonometer body from those used in humans and species with similar size eyes. Tonometers with tips with biprism angles of 48 degrees and an applied weight of 25 mg per Goldmann scale division (2 g full scale) were calibrated for the rat against manometrically measured IOP. Tonometers, thus modified, were then used in conscious, unsedated rats.
In conscious rats the measured mean Goldmann value was 15.5 +/- 0.6 mm Hg (confidence interval = 14.1, 16.6 mm Hg). This was the plateau level reached after the repeated applanations (approximately 10) required to eliminate an artifactual decline in initial Goldmann readings, which was larger than that in humans.
The Goldmann applanation tonometer was modified to measure IOP in the conscious, unsedated rat. This instrument, the standard for measuring this key physiological parameter in the human eye, can now be applied to the laboratory rat. This may advance the use of this important animal as a model in IOP and glaucoma research.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>11157864</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-0404 |
| ispartof | Investigative ophthalmology & visual science, 2001-02, Vol.42 (2), p.340-342 |
| issn | 0146-0404 1552-5783 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70620673 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological and medical sciences Calibration Consciousness Glaucoma and intraocular pressure Intraocular Pressure Medical sciences Ophthalmology Rats Rats, Inbred BN Tonometry, Ocular - methods |
| title | Goldmann Applanation Tonometry in the Conscious Rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T22%3A02%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Goldmann%20Applanation%20Tonometry%20in%20the%20Conscious%20Rat&rft.jtitle=Investigative%20ophthalmology%20&%20visual%20science&rft.au=Cohan,%20Bruce%20E&rft.date=2001-02&rft.volume=42&rft.issue=2&rft.spage=340&rft.epage=342&rft.pages=340-342&rft.issn=0146-0404&rft.eissn=1552-5783&rft.coden=IOVSDA&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E70620673%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70620673&rft_id=info:pmid/11157864&rfr_iscdi=true |