Expansion of normal and leukemic human hematopoietic stem/progenitor cells requires Rac-mediated interaction with stromal cells

Objective To determine the involvement of Rac signaling in self-renewal and expansion on bone marrow stroma of normal CD34+ cells vs leukemic CD34+ cells from acute myeloid leukemia (AML) patients. Materials and Methods Rac signaling was modulated by retroviral introduction of Rac1-N17, Rac1-V12, or...

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Veröffentlicht in:	Experimental hematology 2007-05, Vol.35 (5), p.782-792
Hauptverfasser:	Rozenveld-Geugien, Marjan, Baas, Inge O, van Gosliga, Djoke, Vellenga, Edo, Schuringa, Jan Jacob
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Aminoquinolines - pharmacology Antigens, CD34 - immunology Cell Adhesion - drug effects Cell Adhesion - physiology Cell Communication - physiology Cell Culture Techniques - methods Cell Movement - drug effects Cell Movement - physiology Cell Proliferation - drug effects Dose-Response Relationship, Drug Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - physiology Humans Leukemia, Myeloid - metabolism Neoplastic Stem Cells Pyrimidines - pharmacology rac GTP-Binding Proteins - antagonists & inhibitors rac GTP-Binding Proteins - physiology Signal Transduction - drug effects Signal Transduction - physiology Stromal Cells - cytology Stromal Cells - drug effects Stromal Cells - physiology
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