Activation of deoxycytidine kinase by inhibition of DNA synthesis in human lymphocytes

Deoxycytidine kinase (dCK, EC.2.7.1.74) is a key enzyme in the intracellular metabolism of 2-chlorodeoxyadenosine, 1-β- d-arabinofuranosylcytosine, difluorodeoxycytidine, and other drugs used in chemotherapy of different leukaemias and solid tumours. Recently, stimulation of dCK activity was shown b...

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Veröffentlicht in:	Biochemical pharmacology 2001-01, Vol.61 (2), p.191-197
Hauptverfasser:	Csapó, Zsolt, Sasvári-Székely, Mária, Spasokoukotskaja, Tatjana, Talianidis, Iannis, Eriksson, Staffan, Staub, Mária
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Aphidicolin Aphidicolin - pharmacology Biological and medical sciences Deoxycytidine kinase Deoxycytidine Kinase - drug effects Deoxycytidine Kinase - isolation & purification Deoxycytidine Kinase - metabolism DNA - biosynthesis DNA - drug effects DNA synthesis Enzyme Activation Enzyme Inhibitors - pharmacology General aspects HL-60 Cells Human Humans Lymphocyte Lymphocytes - drug effects Lymphocytes - enzymology Medical sciences Nucleic Acid Synthesis Inhibitors Pharmacology. Drug treatments Phosphoprotein Phosphatases - metabolism Phosphorylation
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