Cytokine-Induced Bronchoconstriction in Precision-Cut Lung Slices Is Dependent upon Cyclooxygenase-2 and Thromboxane Receptor Activation

Cytokines play an essential role in the regulation of inflammatory responses. The effects of cytokines on lung functions are less well known and their study in vivo is complicated by the attraction of leukocytes to the inflamed sites. Recently the model of precision-cut lung slices was developed, wh...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2001-02, Vol.24 (2), p.139-145
Hauptverfasser:	Martin, Christian, Uhlig, Stefan, Ullrich, Volker
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchoconstriction - drug effects Cyclooxygenase 2 Cytokines - pharmacology DNA Primers - chemistry Epithelial Cells - drug effects Epithelial Cells - enzymology Female Gene Expression Image Processing, Computer-Assisted Immunoenzyme Techniques In Vitro Techniques Interferon-gamma - pharmacology Interleukin-1 - pharmacology Isoenzymes - genetics Isoenzymes - metabolism Leukotrienes - analysis Lung - drug effects Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Rats Rats, Wistar Receptors, Thromboxane - genetics Receptors, Thromboxane - metabolism Reverse Transcriptase Polymerase Chain Reaction Thromboxanes - analysis Tumor Necrosis Factor-alpha - pharmacology
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